Healthcare services relaxing natural selection may contribute to increase of dementia incidence
Abstract Ageing and genetic traits can only explain the increasing dementia incidence partially. Advanced healthcare services allow dementia patients to survive natural selection and pass their genes onto the next generation. Country-specific estimates of dementia incidence rates (all ages and 15–49...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-12678-4 |
| _version_ | 1817989740651085824 |
|---|---|
| author | Wenpeng You Renata Henneberg Maciej Henneberg |
| author_facet | Wenpeng You Renata Henneberg Maciej Henneberg |
| author_sort | Wenpeng You |
| collection | DOAJ |
| description | Abstract Ageing and genetic traits can only explain the increasing dementia incidence partially. Advanced healthcare services allow dementia patients to survive natural selection and pass their genes onto the next generation. Country-specific estimates of dementia incidence rates (all ages and 15–49 years old), Biological State Index expressing reduced natural selection (I s ), ageing indexed by life expectancy e(65), GDP PPP and urbanization were obtained for analysing the global and regional correlations between reduced natural selection and dementia incidence with SPSS v. 27. Worldwide, I s significantly, but inversely, correlates with dementia incidence rates for both all ages and 15–49 years old in bivariate correlations. These relationships remain inversely correlated regardless of the competing contributing effects from ageing, GDP and urbanization in partial correlation model. Results of multiple linear regression (enter) have shown that I s is the significant predictor of dementia incidence among all ages and 15–49 years old. Subsequently, I s was selected as the variable having the greatest influence on dementia incidence in stepwise multiple linear regression. The I s correlated with dementia incidence more strongly in developed population groupings. Worldwide, reduced natural selection may be yet another significant contributor to dementia incidence with special regard to developed populations. |
| first_indexed | 2024-04-14T00:50:52Z |
| format | Article |
| id | doaj.art-85400d71e27044e9b113f8dfb2f40633 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-14T00:50:52Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-85400d71e27044e9b113f8dfb2f406332022-12-22T02:21:49ZengNature PortfolioScientific Reports2045-23222022-05-0112111010.1038/s41598-022-12678-4Healthcare services relaxing natural selection may contribute to increase of dementia incidenceWenpeng You0Renata Henneberg1Maciej Henneberg2Biological Anthropology and Comparative Anatomy Unit, School of Biomedicine, The University of AdelaideBiological Anthropology and Comparative Anatomy Unit, School of Biomedicine, The University of AdelaideBiological Anthropology and Comparative Anatomy Unit, School of Biomedicine, The University of AdelaideAbstract Ageing and genetic traits can only explain the increasing dementia incidence partially. Advanced healthcare services allow dementia patients to survive natural selection and pass their genes onto the next generation. Country-specific estimates of dementia incidence rates (all ages and 15–49 years old), Biological State Index expressing reduced natural selection (I s ), ageing indexed by life expectancy e(65), GDP PPP and urbanization were obtained for analysing the global and regional correlations between reduced natural selection and dementia incidence with SPSS v. 27. Worldwide, I s significantly, but inversely, correlates with dementia incidence rates for both all ages and 15–49 years old in bivariate correlations. These relationships remain inversely correlated regardless of the competing contributing effects from ageing, GDP and urbanization in partial correlation model. Results of multiple linear regression (enter) have shown that I s is the significant predictor of dementia incidence among all ages and 15–49 years old. Subsequently, I s was selected as the variable having the greatest influence on dementia incidence in stepwise multiple linear regression. The I s correlated with dementia incidence more strongly in developed population groupings. Worldwide, reduced natural selection may be yet another significant contributor to dementia incidence with special regard to developed populations.https://doi.org/10.1038/s41598-022-12678-4 |
| spellingShingle | Wenpeng You Renata Henneberg Maciej Henneberg Healthcare services relaxing natural selection may contribute to increase of dementia incidence Scientific Reports |
| title | Healthcare services relaxing natural selection may contribute to increase of dementia incidence |
| title_full | Healthcare services relaxing natural selection may contribute to increase of dementia incidence |
| title_fullStr | Healthcare services relaxing natural selection may contribute to increase of dementia incidence |
| title_full_unstemmed | Healthcare services relaxing natural selection may contribute to increase of dementia incidence |
| title_short | Healthcare services relaxing natural selection may contribute to increase of dementia incidence |
| title_sort | healthcare services relaxing natural selection may contribute to increase of dementia incidence |
| url | https://doi.org/10.1038/s41598-022-12678-4 |
| work_keys_str_mv | AT wenpengyou healthcareservicesrelaxingnaturalselectionmaycontributetoincreaseofdementiaincidence AT renatahenneberg healthcareservicesrelaxingnaturalselectionmaycontributetoincreaseofdementiaincidence AT maciejhenneberg healthcareservicesrelaxingnaturalselectionmaycontributetoincreaseofdementiaincidence |