Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity.
BACKGROUND: Impulsivity is a multidimensional construct which has been associated with dopaminergic neurotransmission. Nonetheless, until this moment, few studies addressed the relationship between different types of impulsivity and the single nucleotide polymorphism caused by a substitution of vali...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3769314?pdf=render |
| _version_ | 1818510167846682624 |
|---|---|
| author | Leandro Fernandes Malloy-Diniz Guilherme Menezes Lage Simone Becho Campos Jonas Jardim de Paula Danielle de Souza Costa Marco Aurélio Romano-Silva Débora Marques de Miranda Humberto Correa |
| author_facet | Leandro Fernandes Malloy-Diniz Guilherme Menezes Lage Simone Becho Campos Jonas Jardim de Paula Danielle de Souza Costa Marco Aurélio Romano-Silva Débora Marques de Miranda Humberto Correa |
| author_sort | Leandro Fernandes Malloy-Diniz |
| collection | DOAJ |
| description | BACKGROUND: Impulsivity is a multidimensional construct which has been associated with dopaminergic neurotransmission. Nonetheless, until this moment, few studies addressed the relationship between different types of impulsivity and the single nucleotide polymorphism caused by a substitution of valine (val) with methionine (met) in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met). The present study aimed to investigate the association between val158met COMT polymorphism and impulsive behavior measured by two neuropsychological tests. METHODOLOGY/PRINCIPAL FINDINGS: We administered two neuropsychological tests, a Continuous Performance Task and the Iowa Gambling Task were applied to 195 healthy participants to characterize their levels of motor, attentional and non-planning impulsivity. Then, subjects were grouped by genotype, and their scores on impulsivity measures were compared. There were no significant differences between group scores on attentional and motor impulsivity. Those participants who were homozygous for the met allele performed worse in the Iowa Gambling Task than val/val and val/met subjects. CONCLUSIONS/SIGNIFICANCE: Our results suggest that met allele of val158met COMT polymorphism is associated with poor performance in decision-making/cognitive impulsivity task. The results reinforce the hypothesis that val and met alleles of the val158met polymorphism show functional dissociation and are related to different prefrontal processes. |
| first_indexed | 2024-12-10T22:55:29Z |
| format | Article |
| id | doaj.art-854065cc980e4fca97afddc2a20ebb95 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T22:55:29Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-854065cc980e4fca97afddc2a20ebb952022-12-22T01:30:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7350910.1371/journal.pone.0073509Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity.Leandro Fernandes Malloy-DinizGuilherme Menezes LageSimone Becho CamposJonas Jardim de PaulaDanielle de Souza CostaMarco Aurélio Romano-SilvaDébora Marques de MirandaHumberto CorreaBACKGROUND: Impulsivity is a multidimensional construct which has been associated with dopaminergic neurotransmission. Nonetheless, until this moment, few studies addressed the relationship between different types of impulsivity and the single nucleotide polymorphism caused by a substitution of valine (val) with methionine (met) in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met). The present study aimed to investigate the association between val158met COMT polymorphism and impulsive behavior measured by two neuropsychological tests. METHODOLOGY/PRINCIPAL FINDINGS: We administered two neuropsychological tests, a Continuous Performance Task and the Iowa Gambling Task were applied to 195 healthy participants to characterize their levels of motor, attentional and non-planning impulsivity. Then, subjects were grouped by genotype, and their scores on impulsivity measures were compared. There were no significant differences between group scores on attentional and motor impulsivity. Those participants who were homozygous for the met allele performed worse in the Iowa Gambling Task than val/val and val/met subjects. CONCLUSIONS/SIGNIFICANCE: Our results suggest that met allele of val158met COMT polymorphism is associated with poor performance in decision-making/cognitive impulsivity task. The results reinforce the hypothesis that val and met alleles of the val158met polymorphism show functional dissociation and are related to different prefrontal processes.http://europepmc.org/articles/PMC3769314?pdf=render |
| spellingShingle | Leandro Fernandes Malloy-Diniz Guilherme Menezes Lage Simone Becho Campos Jonas Jardim de Paula Danielle de Souza Costa Marco Aurélio Romano-Silva Débora Marques de Miranda Humberto Correa Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity. PLoS ONE |
| title | Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity. |
| title_full | Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity. |
| title_fullStr | Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity. |
| title_full_unstemmed | Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity. |
| title_short | Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity. |
| title_sort | association between the catechol o methyltransferase comt val158met polymorphism and different dimensions of impulsivity |
| url | http://europepmc.org/articles/PMC3769314?pdf=render |
| work_keys_str_mv | AT leandrofernandesmalloydiniz associationbetweenthecatecholomethyltransferasecomtval158metpolymorphismanddifferentdimensionsofimpulsivity AT guilhermemenezeslage associationbetweenthecatecholomethyltransferasecomtval158metpolymorphismanddifferentdimensionsofimpulsivity AT simonebechocampos associationbetweenthecatecholomethyltransferasecomtval158metpolymorphismanddifferentdimensionsofimpulsivity AT jonasjardimdepaula associationbetweenthecatecholomethyltransferasecomtval158metpolymorphismanddifferentdimensionsofimpulsivity AT danielledesouzacosta associationbetweenthecatecholomethyltransferasecomtval158metpolymorphismanddifferentdimensionsofimpulsivity AT marcoaurelioromanosilva associationbetweenthecatecholomethyltransferasecomtval158metpolymorphismanddifferentdimensionsofimpulsivity AT deboramarquesdemiranda associationbetweenthecatecholomethyltransferasecomtval158metpolymorphismanddifferentdimensionsofimpulsivity AT humbertocorrea associationbetweenthecatecholomethyltransferasecomtval158metpolymorphismanddifferentdimensionsofimpulsivity |