Pharmacokinetics and pharmacodynamics of rebamipide. New possibilities of therapy: A review
The MedLine database contains 570 publications, including 71 randomized clinical trials and 6 meta-analyses on the rebamipide molecule in 2022. Indications for the use of rebamipide are gastric ulcer, chronic gastritis with hyperacidityin the acute stage, erosive gastritis, prevention of damage to t...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2023-01-01
|
| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/121855/96715 |
| _version_ | 1797846631709671424 |
|---|---|
| author | Natalia V. Bakulina Sergey V. Tikhonov Sergey V. Okovityi Elena A. Lutaenko Alexandеr O. Bolshakov Veronika A. Prikhodko Anna S. Nekrasova |
| author_facet | Natalia V. Bakulina Sergey V. Tikhonov Sergey V. Okovityi Elena A. Lutaenko Alexandеr O. Bolshakov Veronika A. Prikhodko Anna S. Nekrasova |
| author_sort | Natalia V. Bakulina |
| collection | DOAJ |
| description | The MedLine database contains 570 publications, including 71 randomized clinical trials and 6 meta-analyses on the rebamipide molecule in 2022. Indications for the use of rebamipide are gastric ulcer, chronic gastritis with hyperacidityin the acute stage, erosive gastritis, prevention of damage to the gastrointestinal mucosa while taking non-steroidal anti-inflammatory drugs, eradication of Helicobacter pylori. Currently trials are studying the efficacy and safety of the drug in gouty and rheumatoid arthritis, osteoarthritis, Sjgren's syndrome, bronchial asthma, vitiligo, atherosclerosis, diseases of the kidneys and liver; using in traumatology to accelerate bone regeneration; in ophthalmology to improve the regeneration of corneal epithelium; in oncology to reduce inflammatory changes in the oral mucosa after chemoradiotherapy. The review article is about the main pharmacokinetic and pharmacodynamic characteristics of rebamipide. A detailed understanding of pharmacodynamics and pharmacokinetics allows for individual selection of therapy based on the characteristics of the patient's body gender, age, comorbidities; choose the optimal route of administration and dosing regimen; predict adverse effects and drug interactions; be determined with new clinical indications. |
| first_indexed | 2024-04-09T17:58:05Z |
| format | Article |
| id | doaj.art-854065ccdd4f4d0788bc00d7afd90d2c |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-09T17:58:05Z |
| publishDate | 2023-01-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-854065ccdd4f4d0788bc00d7afd90d2c2023-04-14T13:31:51Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422023-01-0194121431143710.26442/00403660.2022.12.20200078236Pharmacokinetics and pharmacodynamics of rebamipide. New possibilities of therapy: A reviewNatalia V. Bakulina0https://orcid.org/0000-0003-4075-4096Sergey V. Tikhonov1https://orcid.org/0000-0001-5720-3528Sergey V. Okovityi2https://orcid.org/0000-0003-4294-5531Elena A. Lutaenko3https://orcid.org/0000-0003-3472-3728Alexandеr O. Bolshakov4https://orcid.org/0000-0002-5103-5778Veronika A. Prikhodko5https://orcid.org/0000-0002-4690-1811Anna S. Nekrasova6https://orcid.org/0000-0001-5198-9902Mechnikov North-Western State Medical UniversityMechnikov North-Western State Medical UniversitySaint Petersburg State Chemical Pharmaceutical UniversityMechnikov North-Western State Medical UniversityMechnikov North-Western State Medical UniversitySaint Petersburg State Chemical Pharmaceutical UniversityMechnikov North-Western State Medical UniversityThe MedLine database contains 570 publications, including 71 randomized clinical trials and 6 meta-analyses on the rebamipide molecule in 2022. Indications for the use of rebamipide are gastric ulcer, chronic gastritis with hyperacidityin the acute stage, erosive gastritis, prevention of damage to the gastrointestinal mucosa while taking non-steroidal anti-inflammatory drugs, eradication of Helicobacter pylori. Currently trials are studying the efficacy and safety of the drug in gouty and rheumatoid arthritis, osteoarthritis, Sjgren's syndrome, bronchial asthma, vitiligo, atherosclerosis, diseases of the kidneys and liver; using in traumatology to accelerate bone regeneration; in ophthalmology to improve the regeneration of corneal epithelium; in oncology to reduce inflammatory changes in the oral mucosa after chemoradiotherapy. The review article is about the main pharmacokinetic and pharmacodynamic characteristics of rebamipide. A detailed understanding of pharmacodynamics and pharmacokinetics allows for individual selection of therapy based on the characteristics of the patient's body gender, age, comorbidities; choose the optimal route of administration and dosing regimen; predict adverse effects and drug interactions; be determined with new clinical indications.https://ter-arkhiv.ru/0040-3660/article/viewFile/121855/96715rebamipidepharmacokineticspharmacodynamicsabsorptionfirst pass metabolismbioavailabilityprotein bindingvolume of distributionmetabolismexcretion |
| spellingShingle | Natalia V. Bakulina Sergey V. Tikhonov Sergey V. Okovityi Elena A. Lutaenko Alexandеr O. Bolshakov Veronika A. Prikhodko Anna S. Nekrasova Pharmacokinetics and pharmacodynamics of rebamipide. New possibilities of therapy: A review Терапевтический архив rebamipide pharmacokinetics pharmacodynamics absorption first pass metabolism bioavailability protein binding volume of distribution metabolism excretion |
| title | Pharmacokinetics and pharmacodynamics of rebamipide. New possibilities of therapy: A review |
| title_full | Pharmacokinetics and pharmacodynamics of rebamipide. New possibilities of therapy: A review |
| title_fullStr | Pharmacokinetics and pharmacodynamics of rebamipide. New possibilities of therapy: A review |
| title_full_unstemmed | Pharmacokinetics and pharmacodynamics of rebamipide. New possibilities of therapy: A review |
| title_short | Pharmacokinetics and pharmacodynamics of rebamipide. New possibilities of therapy: A review |
| title_sort | pharmacokinetics and pharmacodynamics of rebamipide new possibilities of therapy a review |
| topic | rebamipide pharmacokinetics pharmacodynamics absorption first pass metabolism bioavailability protein binding volume of distribution metabolism excretion |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/121855/96715 |
| work_keys_str_mv | AT nataliavbakulina pharmacokineticsandpharmacodynamicsofrebamipidenewpossibilitiesoftherapyareview AT sergeyvtikhonov pharmacokineticsandpharmacodynamicsofrebamipidenewpossibilitiesoftherapyareview AT sergeyvokovityi pharmacokineticsandpharmacodynamicsofrebamipidenewpossibilitiesoftherapyareview AT elenaalutaenko pharmacokineticsandpharmacodynamicsofrebamipidenewpossibilitiesoftherapyareview AT alexanderobolshakov pharmacokineticsandpharmacodynamicsofrebamipidenewpossibilitiesoftherapyareview AT veronikaaprikhodko pharmacokineticsandpharmacodynamicsofrebamipidenewpossibilitiesoftherapyareview AT annasnekrasova pharmacokineticsandpharmacodynamicsofrebamipidenewpossibilitiesoftherapyareview |