Mitochondrial uncoupler DNP induces coexistence of dual-state hyper-energy metabolism leading to tumor growth advantage in human glioma xenografts

Mitochondrial uncoupler DNP induces coexistence of dual-state hyper-energy metabolism leading to tumor growth advantage in human glioma xenografts

IntroductionCancer bioenergetics is an essential hallmark of neoplastic transformation. Warburg postulated that mitochondrial OXPHOS is impaired in cancer cells, leading to aerobic glycolysis as the primary metabolic pathway. However, mitochondrial function is altered but not entirely compromised in...

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Bibliographic Details
Main Authors: Yogesh Rai, Saurabh Singh, Sanjay Pandey, Dhananjay Sah, Raj Kumar Sah, B. G. Roy, Bilikere S. Dwarakanath, Anant Narayan Bhatt
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
Warburg effect
oxidative phosphorylation
glioma tumor
cancer cell metabolism
tumor bioenergetics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1063531/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1063531/full

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