Influence of renal denervation on atrial tachyarrhythmia recurrence in patients with resistant hypertension and atrial fibrillation
<p>Objective. The aim of this prospective randomized study was to assess the impact of renal artery denervation on patients with refractory AF and drug resistant hypertension, for whom pulmonary vein isolation (PVI) was recommended.<br />Methods. Patients with symptomatic paroxysmal or p...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Meshalkin National Medical Research Center
2016-01-01
|
| Series: | Патология кровообращения и кардиохирургия |
| Subjects: | |
| Online Access: | http://journalmeshalkin.ru/index.php/heartjournal/article/view/270 |
| _version_ | 1797763786090741760 |
|---|---|
| author | Д. А. Заманов А. Ю. Дмитриев С. И. Антонов Л. В. Пристромова Э. Э. Иваницкая А. В. Пустовойтов Е. Е. Корчагин С. Н. Артеменко В. В. Шабанов А. Б. Романов Е. А. Покушалов |
| author_facet | Д. А. Заманов А. Ю. Дмитриев С. И. Антонов Л. В. Пристромова Э. Э. Иваницкая А. В. Пустовойтов Е. Е. Корчагин С. Н. Артеменко В. В. Шабанов А. Б. Романов Е. А. Покушалов |
| author_sort | Д. А. Заманов |
| collection | DOAJ |
| description | <p>Objective. The aim of this prospective randomized study was to assess the impact of renal artery denervation on patients with refractory AF and drug resistant hypertension, for whom pulmonary vein isolation (PVI) was recommended.<br />Methods. Patients with symptomatic paroxysmal or persistent AF refractory to ≥2 antiarrhythmic drugs and drug-resistant hypertension (systolic blood pressure >160 mm Hg despite triple drug therapy) were eligible for enrolment. 50 consenting patients were randomized to PVI only (n = 25) or PVI with renal artery denervation (n = 25). All patients were followed during 18 months to assess sinus rhythm stability and to monitor blood pressure changes.<br />Results. Out of 25, 16 (64%) patients treated with PVI and renal denervation versus 6 (24%) of the 25 patients in the PVI-only group (p=0.004, log-rank test) were AF-free at 18-month post ablation follow-up. At the end of follow-up, significant reductions in systolic (–27±4 mm Hg) and diastolic blood pressure (–11±2 mm Hg) were observed in patients treated with PVI with renal denervation, with no significant changes in the PVI only group. <br />Conclusion. Renal artery denervation combined with PVI reduces AF recurrence and systolic/diastolic blood pressure, as compared with conventional AF ablation, in patients with drug-resistant hypertension and AF.</p> |
| first_indexed | 2024-03-12T19:46:17Z |
| format | Article |
| id | doaj.art-8540e218e810451c8a50debeba667d2b |
| institution | Directory Open Access Journal |
| issn | 1681-3472 2500-3119 |
| language | English |
| last_indexed | 2024-03-12T19:46:17Z |
| publishDate | 2016-01-01 |
| publisher | Meshalkin National Medical Research Center |
| record_format | Article |
| series | Патология кровообращения и кардиохирургия |
| spelling | doaj.art-8540e218e810451c8a50debeba667d2b2023-08-02T03:31:35ZengMeshalkin National Medical Research CenterПатология кровообращения и кардиохирургия1681-34722500-31192016-01-01194919810.21688/1681-3472-2015-4-91-98982Influence of renal denervation on atrial tachyarrhythmia recurrence in patients with resistant hypertension and atrial fibrillationД. А. Заманов0А. Ю. Дмитриев1С. И. Антонов2Л. В. Пристромова3Э. Э. Иваницкая4А. В. Пустовойтов5Е. Е. Корчагин6С. Н. Артеменко7В. В. Шабанов8А. Б. Романов9Е. А. Покушалов10Краевая клиническая больница, 660022, Красноярск, ул. Партизана Железняка, 3аКраевая клиническая больница, 660022, Красноярск, ул. Партизана Железняка, 3аКраевая клиническая больница, 660022, Красноярск, ул. Партизана Железняка, 3аКраевая клиническая больница, 660022, Красноярск, ул. Партизана Железняка, 3аКраевая клиническая больница, 660022, Красноярск, ул. Партизана Железняка, 3аКраевая клиническая больница, 660022, Красноярск, ул. Партизана Железняка, 3аКраевая клиническая больница, 660022, Красноярск, ул. Партизана Железняка, 3аНовосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15<p>Objective. The aim of this prospective randomized study was to assess the impact of renal artery denervation on patients with refractory AF and drug resistant hypertension, for whom pulmonary vein isolation (PVI) was recommended.<br />Methods. Patients with symptomatic paroxysmal or persistent AF refractory to ≥2 antiarrhythmic drugs and drug-resistant hypertension (systolic blood pressure >160 mm Hg despite triple drug therapy) were eligible for enrolment. 50 consenting patients were randomized to PVI only (n = 25) or PVI with renal artery denervation (n = 25). All patients were followed during 18 months to assess sinus rhythm stability and to monitor blood pressure changes.<br />Results. Out of 25, 16 (64%) patients treated with PVI and renal denervation versus 6 (24%) of the 25 patients in the PVI-only group (p=0.004, log-rank test) were AF-free at 18-month post ablation follow-up. At the end of follow-up, significant reductions in systolic (–27±4 mm Hg) and diastolic blood pressure (–11±2 mm Hg) were observed in patients treated with PVI with renal denervation, with no significant changes in the PVI only group. <br />Conclusion. Renal artery denervation combined with PVI reduces AF recurrence and systolic/diastolic blood pressure, as compared with conventional AF ablation, in patients with drug-resistant hypertension and AF.</p>http://journalmeshalkin.ru/index.php/heartjournal/article/view/270Фибрилляция предсердийДенервация почечных артерийРенальная денервацияРезистентная артериальная гипертензия |
| spellingShingle | Д. А. Заманов А. Ю. Дмитриев С. И. Антонов Л. В. Пристромова Э. Э. Иваницкая А. В. Пустовойтов Е. Е. Корчагин С. Н. Артеменко В. В. Шабанов А. Б. Романов Е. А. Покушалов Influence of renal denervation on atrial tachyarrhythmia recurrence in patients with resistant hypertension and atrial fibrillation Патология кровообращения и кардиохирургия Фибрилляция предсердий Денервация почечных артерий Ренальная денервация Резистентная артериальная гипертензия |
| title | Influence of renal denervation on atrial tachyarrhythmia recurrence in patients with resistant hypertension and atrial fibrillation |
| title_full | Influence of renal denervation on atrial tachyarrhythmia recurrence in patients with resistant hypertension and atrial fibrillation |
| title_fullStr | Influence of renal denervation on atrial tachyarrhythmia recurrence in patients with resistant hypertension and atrial fibrillation |
| title_full_unstemmed | Influence of renal denervation on atrial tachyarrhythmia recurrence in patients with resistant hypertension and atrial fibrillation |
| title_short | Influence of renal denervation on atrial tachyarrhythmia recurrence in patients with resistant hypertension and atrial fibrillation |
| title_sort | influence of renal denervation on atrial tachyarrhythmia recurrence in patients with resistant hypertension and atrial fibrillation |
| topic | Фибрилляция предсердий Денервация почечных артерий Ренальная денервация Резистентная артериальная гипертензия |
| url | http://journalmeshalkin.ru/index.php/heartjournal/article/view/270 |
| work_keys_str_mv | AT dazamanov influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation AT aûdmitriev influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation AT siantonov influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation AT lvpristromova influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation AT ééivanickaâ influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation AT avpustovojtov influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation AT eekorčagin influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation AT snartemenko influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation AT vvšabanov influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation AT abromanov influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation AT eapokušalov influenceofrenaldenervationonatrialtachyarrhythmiarecurrenceinpatientswithresistanthypertensionandatrialfibrillation |