Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy
Coronavirus disease 2019 (COVID-19) pandemic has killed huge populations throughout the world and acts as a high-risk factor for elderly and young immune-suppressed patients. There is a critical need to build up secure, reliable, and efficient drugs against to the infection of severe acute respirato...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.933824/full |
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| author | Manali Singh Manali Singh Kuldeep Jayant Dipti Singh Shivani Bhutani Nitesh Kumar Poddar Anis Ahmad Chaudhary Salah-Ud-Din Khan Mohd Adnan Arif Jamal Siddiqui Md Imtaiyaz Hassan Faez Iqbal Khan Faez Iqbal Khan Dakun Lai Shahanavaj Khan Shahanavaj Khan Shahanavaj Khan |
| author_facet | Manali Singh Manali Singh Kuldeep Jayant Dipti Singh Shivani Bhutani Nitesh Kumar Poddar Anis Ahmad Chaudhary Salah-Ud-Din Khan Mohd Adnan Arif Jamal Siddiqui Md Imtaiyaz Hassan Faez Iqbal Khan Faez Iqbal Khan Dakun Lai Shahanavaj Khan Shahanavaj Khan Shahanavaj Khan |
| author_sort | Manali Singh |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) pandemic has killed huge populations throughout the world and acts as a high-risk factor for elderly and young immune-suppressed patients. There is a critical need to build up secure, reliable, and efficient drugs against to the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Bioactive compounds of Ashwagandha [Withania somnifera (L.) Dunal] may implicate as herbal medicine for the management and treatment of patients infected by SARS-CoV-2 infection. The aim of the current work is to update the knowledge of SARS-CoV-2 infection and information about the implication of various compounds of medicinal plant Withania somnifera with minimum side effects on the patients’ organs. The herbal medicine Withania somnifera has an excellent antiviral activity that could be implicated in the management and treatment of flu and flu-like diseases connected with SARS-CoV-2. The analysis was performed by systematically re-evaluating the published articles related to the infection of SARS-CoV-2 and the herbal medicine Withania somnifera. In the current review, we have provided the important information and data of various bioactive compounds of Withania somnifera such as Withanoside V, Withanone, Somniferine, and some other compounds, which can possibly help in the management and treatment of SARS-CoV-2 infection. Withania somnifera has proved its potential for maintaining immune homeostasis of the body, inflammation regulation, pro-inflammatory cytokines suppression, protection of multiple organs, anti-viral, anti-stress, and anti-hypertensive properties. Withanoside V has the potential to inhibit the main proteases (Mpro) of SARS-CoV-2. At present, synthetic adjuvant vaccines are used against COVID-19. Available information showed the antiviral activity in Withanoside V of Withania somnifera, which may explore as herbal medicine against to SARS-CoV-2 infection after standardization of parameters of drug development and formulation in near future. |
| first_indexed | 2024-12-10T19:50:49Z |
| format | Article |
| id | doaj.art-854179e1c5fb4b54be60321832e3e540 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-10T19:50:49Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-854179e1c5fb4b54be60321832e3e5402022-12-22T01:35:48ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-08-011210.3389/fcimb.2022.933824933824Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapyManali Singh0Manali Singh1Kuldeep Jayant2Dipti Singh3Shivani Bhutani4Nitesh Kumar Poddar5Anis Ahmad Chaudhary6Salah-Ud-Din Khan7Mohd Adnan8Arif Jamal Siddiqui9Md Imtaiyaz Hassan10Faez Iqbal Khan11Faez Iqbal Khan12Dakun Lai13Shahanavaj Khan14Shahanavaj Khan15Shahanavaj Khan16Department of Biotechnology, Invertis University, Bareilly, Uttar Pradesh, IndiaDepartment of Biochemistry, C.B.S.H, G.B Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, IndiaDepartment of Agricultural and Food Engineering, IIT Kharagpur, West Bengal, Kharagpur, IndiaDepartment of Biochemistry, C.B.S.H, G.B Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, IndiaDepartment of Biotechnology, Invertis University, Bareilly, Uttar Pradesh, IndiaDepartment of Biosciences, Manipal University Jaipur, Jaipur, Rajasthan, IndiaDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi ArabiaDepartment of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi ArabiaDepartment of Biology, College of Science, University of Hail, Hail, Saudi ArabiaDepartment of Biology, College of Science, University of Hail, Hail, Saudi ArabiaCenter for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, IndiaDepartment of Biological Sciences, School of Science, Xi’an Jiaotong-Liverpool University, Suzhou, China0School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China0School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China1Department of Health Sciences, Novel Global Community Educational Foundation 7 Peterlee Place, Hebersham, NSW, Australia2Department of Medical Lab Technology, Indian Institute of Health and Technology (IIHT), Deoband, Saharanpur, UP, India3Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaCoronavirus disease 2019 (COVID-19) pandemic has killed huge populations throughout the world and acts as a high-risk factor for elderly and young immune-suppressed patients. There is a critical need to build up secure, reliable, and efficient drugs against to the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Bioactive compounds of Ashwagandha [Withania somnifera (L.) Dunal] may implicate as herbal medicine for the management and treatment of patients infected by SARS-CoV-2 infection. The aim of the current work is to update the knowledge of SARS-CoV-2 infection and information about the implication of various compounds of medicinal plant Withania somnifera with minimum side effects on the patients’ organs. The herbal medicine Withania somnifera has an excellent antiviral activity that could be implicated in the management and treatment of flu and flu-like diseases connected with SARS-CoV-2. The analysis was performed by systematically re-evaluating the published articles related to the infection of SARS-CoV-2 and the herbal medicine Withania somnifera. In the current review, we have provided the important information and data of various bioactive compounds of Withania somnifera such as Withanoside V, Withanone, Somniferine, and some other compounds, which can possibly help in the management and treatment of SARS-CoV-2 infection. Withania somnifera has proved its potential for maintaining immune homeostasis of the body, inflammation regulation, pro-inflammatory cytokines suppression, protection of multiple organs, anti-viral, anti-stress, and anti-hypertensive properties. Withanoside V has the potential to inhibit the main proteases (Mpro) of SARS-CoV-2. At present, synthetic adjuvant vaccines are used against COVID-19. Available information showed the antiviral activity in Withanoside V of Withania somnifera, which may explore as herbal medicine against to SARS-CoV-2 infection after standardization of parameters of drug development and formulation in near future.https://www.frontiersin.org/articles/10.3389/fcimb.2022.933824/fullSARS-CoV-2ACE2 receptorsWithania somniferaAshwagandhaCOVID-19targeted therapy |
| spellingShingle | Manali Singh Manali Singh Kuldeep Jayant Dipti Singh Shivani Bhutani Nitesh Kumar Poddar Anis Ahmad Chaudhary Salah-Ud-Din Khan Mohd Adnan Arif Jamal Siddiqui Md Imtaiyaz Hassan Faez Iqbal Khan Faez Iqbal Khan Dakun Lai Shahanavaj Khan Shahanavaj Khan Shahanavaj Khan Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy Frontiers in Cellular and Infection Microbiology SARS-CoV-2 ACE2 receptors Withania somnifera Ashwagandha COVID-19 targeted therapy |
| title | Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy |
| title_full | Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy |
| title_fullStr | Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy |
| title_full_unstemmed | Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy |
| title_short | Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy |
| title_sort | withania somnifera l dunal ashwagandha for the possible therapeutics and clinical management of sars cov 2 infection plant based drug discovery and targeted therapy |
| topic | SARS-CoV-2 ACE2 receptors Withania somnifera Ashwagandha COVID-19 targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.933824/full |
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