Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila
Abstract Although painful stimuli elicit defensive responses including escape behavior for survival, starved animals often prioritize feeding over escape even in a noxious environment. This behavioral priority is typically mediated by suppression of noxious inputs through descending control in the b...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-42202-9 |
| _version_ | 1797558388930904064 |
|---|---|
| author | Mami Nakamizo-Dojo Kenichi Ishii Jiro Yoshino Masato Tsuji Kazuo Emoto |
| author_facet | Mami Nakamizo-Dojo Kenichi Ishii Jiro Yoshino Masato Tsuji Kazuo Emoto |
| author_sort | Mami Nakamizo-Dojo |
| collection | DOAJ |
| description | Abstract Although painful stimuli elicit defensive responses including escape behavior for survival, starved animals often prioritize feeding over escape even in a noxious environment. This behavioral priority is typically mediated by suppression of noxious inputs through descending control in the brain, yet underlying molecular and cellular mechanisms are incompletely understood. Here we identify a cluster of GABAergic neurons in Drosophila larval brain, designated as SEZ-localized Descending GABAergic neurons (SDGs), that project descending axons onto the axon terminals of the peripheral nociceptive neurons and prevent presynaptic activity through GABAB receptors. Remarkably, glucose feeding to starved larvae causes sustained activation of SDGs through glucose-sensing neurons and subsequent insulin signaling in SDGs, which attenuates nociception and thereby suppresses escape behavior in response to multiple noxious stimuli. These findings illustrate a neural mechanism by which sugar sensing neurons in the brain engages descending GABAergic neurons in nociceptive gating to achieve hierarchical interaction between feeding and escape behavior. |
| first_indexed | 2024-03-10T17:29:48Z |
| format | Article |
| id | doaj.art-8543d2e0328d4313bbbe136c96bac50d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:29:48Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8543d2e0328d4313bbbe136c96bac50d2023-11-20T10:03:33ZengNature PortfolioNature Communications2041-17232023-10-0114111810.1038/s41467-023-42202-9Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in DrosophilaMami Nakamizo-Dojo0Kenichi Ishii1Jiro Yoshino2Masato Tsuji3Kazuo Emoto4Department of Biological Sciences, Graduate School of Science, The University of TokyoDepartment of Biological Sciences, Graduate School of Science, The University of TokyoDepartment of Biological Sciences, Graduate School of Science, The University of TokyoDepartment of Biological Sciences, Graduate School of Science, The University of TokyoDepartment of Biological Sciences, Graduate School of Science, The University of TokyoAbstract Although painful stimuli elicit defensive responses including escape behavior for survival, starved animals often prioritize feeding over escape even in a noxious environment. This behavioral priority is typically mediated by suppression of noxious inputs through descending control in the brain, yet underlying molecular and cellular mechanisms are incompletely understood. Here we identify a cluster of GABAergic neurons in Drosophila larval brain, designated as SEZ-localized Descending GABAergic neurons (SDGs), that project descending axons onto the axon terminals of the peripheral nociceptive neurons and prevent presynaptic activity through GABAB receptors. Remarkably, glucose feeding to starved larvae causes sustained activation of SDGs through glucose-sensing neurons and subsequent insulin signaling in SDGs, which attenuates nociception and thereby suppresses escape behavior in response to multiple noxious stimuli. These findings illustrate a neural mechanism by which sugar sensing neurons in the brain engages descending GABAergic neurons in nociceptive gating to achieve hierarchical interaction between feeding and escape behavior.https://doi.org/10.1038/s41467-023-42202-9 |
| spellingShingle | Mami Nakamizo-Dojo Kenichi Ishii Jiro Yoshino Masato Tsuji Kazuo Emoto Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila Nature Communications |
| title | Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila |
| title_full | Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila |
| title_fullStr | Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila |
| title_full_unstemmed | Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila |
| title_short | Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila |
| title_sort | descending gabaergic pathway links brain sugar sensing to peripheral nociceptive gating in drosophila |
| url | https://doi.org/10.1038/s41467-023-42202-9 |
| work_keys_str_mv | AT maminakamizodojo descendinggabaergicpathwaylinksbrainsugarsensingtoperipheralnociceptivegatingindrosophila AT kenichiishii descendinggabaergicpathwaylinksbrainsugarsensingtoperipheralnociceptivegatingindrosophila AT jiroyoshino descendinggabaergicpathwaylinksbrainsugarsensingtoperipheralnociceptivegatingindrosophila AT masatotsuji descendinggabaergicpathwaylinksbrainsugarsensingtoperipheralnociceptivegatingindrosophila AT kazuoemoto descendinggabaergicpathwaylinksbrainsugarsensingtoperipheralnociceptivegatingindrosophila |