SARS-CoV-2 infection and thyroid dysfunction in children
The problem of thyroid dysfunction related to SARS-CoV-2 infection remains unclear in children. Therefore, the study aimed to reveal the interrelationship between thyroid dysfunction and COVID-19 severity as well as to determine optimal cut-off values for screening for thyroid disorders in children...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2023-06-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2023/07/Kozak_95_3.pdf |
| _version_ | 1827787984196337664 |
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| author | K. V. Kozak H. A. Pavlyshyn I. Y. Avramenko O. M. Dyvonyak O. O. Shevchuk K. T. Hlushko |
| author_facet | K. V. Kozak H. A. Pavlyshyn I. Y. Avramenko O. M. Dyvonyak O. O. Shevchuk K. T. Hlushko |
| author_sort | K. V. Kozak |
| collection | DOAJ |
| description | The problem of thyroid dysfunction related to SARS-CoV-2 infection remains unclear in children. Therefore, the study aimed to reveal the interrelationship between thyroid dysfunction and COVID-19 severity as well as to determine optimal cut-off values for screening for thyroid disorders in children. A total number of 90 children aged from 1 month to 17 years were involved in the study. Patients with known thyroid disease were not recruited for the research. A thyroid panel was assessed for all participants that included: free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase (ATPO) antibodies. Statistical analysis was done using the computer software Statistica 13.0. Research has revealed euthyroid sick syndrome (ESS) in 14.10% of SARS-CoV-2 infected children more often among patients with severe COVID-19 and multisystem inflammatory syndrome (33.33%) compared to mild COVID-19 course (6.67%) and moderate disease severity (8.89%) (P < 0.05). Significant correlation relationships were revealed for next values – FT3 and erythrocyte sedimentation rate (ESR) (rs = -0.22; P < 0.05); FT3 and C-reactive protein (CRP) (rs = -0.33; P < 0.05); FT3 and procalcitonin (rs = -0.43; P < 0.05). The next cut-off values for ESS determination were revealed: ESR 18.5 mm/h (AUC 0.803); CRP 11.5 mg/l (AUC 0.763); ferritin 84.8 ng/ml (AUC 0.733). Results suggest that pediatricians should pay attention to the endocrine disruptions by COVID-19 in children. |
| first_indexed | 2024-03-11T16:59:26Z |
| format | Article |
| id | doaj.art-854414c2650b45c19094732f765d5c72 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T16:59:26Z |
| publishDate | 2023-06-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-854414c2650b45c19094732f765d5c722023-10-20T11:59:42ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032023-06-01953122110.15407/ubj95.03.012SARS-CoV-2 infection and thyroid dysfunction in childrenK. V. Kozak0https://orcid.org/0000-0002-5328-4647H. A. Pavlyshyn1I. Y. Avramenko2O. M. Dyvonyak3O. O. Shevchuk4https://orcid.org/0000-0003-2473-6381K. T. Hlushko5https://orcid.org/0000-0002-4777-5300I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineI. Horbachevsky Ternopil National Medical University, Ternopil, UkraineDanylo Halytsky Lviv National Medical University, Lviv, UkraineTernopil Municipal Children’s Hospital, Ternopil, UkraineI. Horbachevsky Ternopil National Medical University, Ternopil, UkraineI. Horbachevsky Ternopil National Medical University, Ternopil, UkraineThe problem of thyroid dysfunction related to SARS-CoV-2 infection remains unclear in children. Therefore, the study aimed to reveal the interrelationship between thyroid dysfunction and COVID-19 severity as well as to determine optimal cut-off values for screening for thyroid disorders in children. A total number of 90 children aged from 1 month to 17 years were involved in the study. Patients with known thyroid disease were not recruited for the research. A thyroid panel was assessed for all participants that included: free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase (ATPO) antibodies. Statistical analysis was done using the computer software Statistica 13.0. Research has revealed euthyroid sick syndrome (ESS) in 14.10% of SARS-CoV-2 infected children more often among patients with severe COVID-19 and multisystem inflammatory syndrome (33.33%) compared to mild COVID-19 course (6.67%) and moderate disease severity (8.89%) (P < 0.05). Significant correlation relationships were revealed for next values – FT3 and erythrocyte sedimentation rate (ESR) (rs = -0.22; P < 0.05); FT3 and C-reactive protein (CRP) (rs = -0.33; P < 0.05); FT3 and procalcitonin (rs = -0.43; P < 0.05). The next cut-off values for ESS determination were revealed: ESR 18.5 mm/h (AUC 0.803); CRP 11.5 mg/l (AUC 0.763); ferritin 84.8 ng/ml (AUC 0.733). Results suggest that pediatricians should pay attention to the endocrine disruptions by COVID-19 in children.http://ukrbiochemjournal.org/wp-content/uploads/2023/07/Kozak_95_3.pdfcovid-19euthyroid sick syndrome in childreninflammatory markers |
| spellingShingle | K. V. Kozak H. A. Pavlyshyn I. Y. Avramenko O. M. Dyvonyak O. O. Shevchuk K. T. Hlushko SARS-CoV-2 infection and thyroid dysfunction in children The Ukrainian Biochemical Journal covid-19 euthyroid sick syndrome in children inflammatory markers |
| title | SARS-CoV-2 infection and thyroid dysfunction in children |
| title_full | SARS-CoV-2 infection and thyroid dysfunction in children |
| title_fullStr | SARS-CoV-2 infection and thyroid dysfunction in children |
| title_full_unstemmed | SARS-CoV-2 infection and thyroid dysfunction in children |
| title_short | SARS-CoV-2 infection and thyroid dysfunction in children |
| title_sort | sars cov 2 infection and thyroid dysfunction in children |
| topic | covid-19 euthyroid sick syndrome in children inflammatory markers |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2023/07/Kozak_95_3.pdf |
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