HUMORAL IMMUNE RESPONSE TO HIV-1 INFECTION AND ALTERED FUNCTION OF B LYMPHOCYTES
Abstract. Over past years, extensive studies were dedicated to pathogenetic mechanisms of HIV-associated disease. In addition to progressive decrease and dysfunction of CD4+T cells, HIV-1 infection also causes intensive defects of humoral immune links. Absence of antiviral immune control leads to in...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/344 |
| Summary: | Abstract. Over past years, extensive studies were dedicated to pathogenetic mechanisms of HIV-associated disease. In addition to progressive decrease and dysfunction of CD4+T cells, HIV-1 infection also causes intensive defects of humoral immune links. Absence of antiviral immune control leads to infection, and this presents great obstacles when treating the disease and developing an effective vaccine against HIV-1 infection. This review article concerns some features of humoral immunity and disturbed B lymphocyte functions that are studied to lesser degree, with respect to HIV infection pathogenesis. |
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| ISSN: | 1563-0625 2313-741X |