Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population
Abstract Background Epilepsy is one of the most common chronic disabling neurologic diseases. The purpose of our study was to investigate whether there is an association between t-PA (tissue plasminogen activator, rs2020918 and rs4646972), PAI-1 (plasminogen activator inhibitor 1, rs1799768) polymor...
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | BMC Neurology |
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| Online Access: | http://link.springer.com/article/10.1186/s12883-019-1239-0 |
| _version_ | 1819024116671315968 |
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| author | Wenxiu Han Pei Jiang Yujin Guo Pengfei Xu Ruili Dang Gongying Li Xin He Dehua Liao Genquan Yan |
| author_facet | Wenxiu Han Pei Jiang Yujin Guo Pengfei Xu Ruili Dang Gongying Li Xin He Dehua Liao Genquan Yan |
| author_sort | Wenxiu Han |
| collection | DOAJ |
| description | Abstract Background Epilepsy is one of the most common chronic disabling neurologic diseases. The purpose of our study was to investigate whether there is an association between t-PA (tissue plasminogen activator, rs2020918 and rs4646972), PAI-1 (plasminogen activator inhibitor 1, rs1799768) polymorphisms and susceptibility to temporal lobe epilepsy (TLE) in Chinese Han population. Method One hundred and twenty-one cases of patients who were diagnosed as TLE and 146 normal controls were enrolled and the genotypes of t-PA and PAI-1 were detected by polymerase chain reaction-ligase detection reaction (PCR-LDR) method after the genomic DNA being extracted from peripheral blood. Result There were significant differences for the genotypic frequencies at the two polymorphic sites in t-PA gene between TLE patients and controls (P = 0.019; P = 0.001). Furthermore, the frequency of rs2020918 (C > T) with T (CT + TT) and rs4646972 (311 bp insertion/−) with 311 bp deletion (311 bp/− + −/−) was significantly higher among TLE patients relative to controls respectively (P = 0.006; P = 0.001). However, no significant difference in genotypic and allelic frequency was found at the polymorphic site in PAI-1 gene between TLE patients and controls (P = 0.735). Conclusion We reported for the first time to our knowledge the significant role of the two SNPs in t-PA gene (rs2020918 and rs4646972) in developing susceptibility to TLE in Chinese Han population. |
| first_indexed | 2024-12-21T04:49:40Z |
| format | Article |
| id | doaj.art-85488c49eb2b4dfabb3f9f7c5c7dee86 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-21T04:49:40Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-85488c49eb2b4dfabb3f9f7c5c7dee862022-12-21T19:15:28ZengBMCBMC Neurology1471-23772019-01-011911610.1186/s12883-019-1239-0Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han populationWenxiu Han0Pei Jiang1Yujin Guo2Pengfei Xu3Ruili Dang4Gongying Li5Xin He6Dehua Liao7Genquan Yan8Institute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital, Jining Medical UniversityInstitute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital, Jining Medical UniversityInstitute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital, Jining Medical UniversityInstitute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital, Jining Medical UniversityInstitute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital, Jining Medical UniversityDepartment of Mental Health, Jining Medical UniversityDepartment of Pharmacy, Second Xiangya Hospital, Central South UniversityDepartment of Pharmacy, Hunan Cancer Hospital, Central South UniversityDepartment of Pharmacy, Shandong Provincial Hospital affiliated to Shandong UniversityAbstract Background Epilepsy is one of the most common chronic disabling neurologic diseases. The purpose of our study was to investigate whether there is an association between t-PA (tissue plasminogen activator, rs2020918 and rs4646972), PAI-1 (plasminogen activator inhibitor 1, rs1799768) polymorphisms and susceptibility to temporal lobe epilepsy (TLE) in Chinese Han population. Method One hundred and twenty-one cases of patients who were diagnosed as TLE and 146 normal controls were enrolled and the genotypes of t-PA and PAI-1 were detected by polymerase chain reaction-ligase detection reaction (PCR-LDR) method after the genomic DNA being extracted from peripheral blood. Result There were significant differences for the genotypic frequencies at the two polymorphic sites in t-PA gene between TLE patients and controls (P = 0.019; P = 0.001). Furthermore, the frequency of rs2020918 (C > T) with T (CT + TT) and rs4646972 (311 bp insertion/−) with 311 bp deletion (311 bp/− + −/−) was significantly higher among TLE patients relative to controls respectively (P = 0.006; P = 0.001). However, no significant difference in genotypic and allelic frequency was found at the polymorphic site in PAI-1 gene between TLE patients and controls (P = 0.735). Conclusion We reported for the first time to our knowledge the significant role of the two SNPs in t-PA gene (rs2020918 and rs4646972) in developing susceptibility to TLE in Chinese Han population.http://link.springer.com/article/10.1186/s12883-019-1239-0t-PA; PAI-1Temporal lobe epilepsyPolymorphism |
| spellingShingle | Wenxiu Han Pei Jiang Yujin Guo Pengfei Xu Ruili Dang Gongying Li Xin He Dehua Liao Genquan Yan Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population BMC Neurology t-PA; PAI-1 Temporal lobe epilepsy Polymorphism |
| title | Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population |
| title_full | Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population |
| title_fullStr | Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population |
| title_full_unstemmed | Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population |
| title_short | Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population |
| title_sort | role of t pa and pai 1 variants in temporal lobe epilepsy in chinese han population |
| topic | t-PA; PAI-1 Temporal lobe epilepsy Polymorphism |
| url | http://link.springer.com/article/10.1186/s12883-019-1239-0 |
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