Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1.
Behavior is used to assess memory and cognitive deficits in animals like Fmr1-null mice that model Fragile X Syndrome, but behavior is a proxy for unknown neural events that define cognitive variables like recollection. We identified an electrophysiological signature of recollection in mouse dorsal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC5790293?pdf=render |
| _version_ | 1818889376919191552 |
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| author | Dino Dvorak Basma Radwan Fraser T Sparks Zoe Nicole Talbot André A Fenton |
| author_facet | Dino Dvorak Basma Radwan Fraser T Sparks Zoe Nicole Talbot André A Fenton |
| author_sort | Dino Dvorak |
| collection | DOAJ |
| description | Behavior is used to assess memory and cognitive deficits in animals like Fmr1-null mice that model Fragile X Syndrome, but behavior is a proxy for unknown neural events that define cognitive variables like recollection. We identified an electrophysiological signature of recollection in mouse dorsal Cornu Ammonis 1 (CA1) hippocampus. During a shocked-place avoidance task, slow gamma (SG) (30-50 Hz) dominates mid-frequency gamma (MG) (70-90 Hz) oscillations 2-3 s before successful avoidance, but not failures. Wild-type (WT) but not Fmr1-null mice rapidly adapt to relocating the shock; concurrently, SG/MG maxima (SGdom) decrease in WT but not in cognitively inflexible Fmr1-null mice. During SGdom, putative pyramidal cell ensembles represent distant locations; during place avoidance, these are avoided places. During shock relocation, WT ensembles represent distant locations near the currently correct shock zone, but Fmr1-null ensembles represent the formerly correct zone. These findings indicate that recollection occurs when CA1 SG dominates MG and that accurate recollection of inappropriate memories explains Fmr1-null cognitive inflexibility. |
| first_indexed | 2024-12-19T17:08:03Z |
| format | Article |
| id | doaj.art-8549272c141d4c8b94e7acd697d6941e |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-19T17:08:03Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-8549272c141d4c8b94e7acd697d6941e2022-12-21T20:13:06ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852018-01-01161e200335410.1371/journal.pbio.2003354Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1.Dino DvorakBasma RadwanFraser T SparksZoe Nicole TalbotAndré A FentonBehavior is used to assess memory and cognitive deficits in animals like Fmr1-null mice that model Fragile X Syndrome, but behavior is a proxy for unknown neural events that define cognitive variables like recollection. We identified an electrophysiological signature of recollection in mouse dorsal Cornu Ammonis 1 (CA1) hippocampus. During a shocked-place avoidance task, slow gamma (SG) (30-50 Hz) dominates mid-frequency gamma (MG) (70-90 Hz) oscillations 2-3 s before successful avoidance, but not failures. Wild-type (WT) but not Fmr1-null mice rapidly adapt to relocating the shock; concurrently, SG/MG maxima (SGdom) decrease in WT but not in cognitively inflexible Fmr1-null mice. During SGdom, putative pyramidal cell ensembles represent distant locations; during place avoidance, these are avoided places. During shock relocation, WT ensembles represent distant locations near the currently correct shock zone, but Fmr1-null ensembles represent the formerly correct zone. These findings indicate that recollection occurs when CA1 SG dominates MG and that accurate recollection of inappropriate memories explains Fmr1-null cognitive inflexibility.http://europepmc.org/articles/PMC5790293?pdf=render |
| spellingShingle | Dino Dvorak Basma Radwan Fraser T Sparks Zoe Nicole Talbot André A Fenton Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1. PLoS Biology |
| title | Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1. |
| title_full | Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1. |
| title_fullStr | Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1. |
| title_full_unstemmed | Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1. |
| title_short | Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1. |
| title_sort | control of recollection by slow gamma dominating mid frequency gamma in hippocampus ca1 |
| url | http://europepmc.org/articles/PMC5790293?pdf=render |
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