Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms
During cell division, chromosome alignment is engendered by connection of microtubules to kinetochores, coordinated by Aurora B and PLK1. Here, the authors show that the RSF1-PLK1 axis creates an activating phosphorylation on T236 in the GT motif of Aurora B and this is indispensable for Aurora B ac...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26220-z |
| _version_ | 1819122987974000640 |
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| author | Ho-Soo Lee Sunwoo Min Ye-Eun Jung Sunyoung Chae June Heo Jae-Ho Lee TaeSoo Kim Ho-Chul Kang Makoto Nakanish Sun-Shin Cha Hyeseong Cho |
| author_facet | Ho-Soo Lee Sunwoo Min Ye-Eun Jung Sunyoung Chae June Heo Jae-Ho Lee TaeSoo Kim Ho-Chul Kang Makoto Nakanish Sun-Shin Cha Hyeseong Cho |
| author_sort | Ho-Soo Lee |
| collection | DOAJ |
| description | During cell division, chromosome alignment is engendered by connection of microtubules to kinetochores, coordinated by Aurora B and PLK1. Here, the authors show that the RSF1-PLK1 axis creates an activating phosphorylation on T236 in the GT motif of Aurora B and this is indispensable for Aurora B activation. |
| first_indexed | 2024-12-22T07:01:11Z |
| format | Article |
| id | doaj.art-85496129839748b6b42b54a47eb01f4f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:01:11Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-85496129839748b6b42b54a47eb01f4f2022-12-21T18:34:48ZengNature PortfolioNature Communications2041-17232021-10-0112111410.1038/s41467-021-26220-zSpatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platformsHo-Soo Lee0Sunwoo Min1Ye-Eun Jung2Sunyoung Chae3June Heo4Jae-Ho Lee5TaeSoo Kim6Ho-Chul Kang7Makoto Nakanish8Sun-Shin Cha9Hyeseong Cho10Department of Biochemistry and Molecular Biology, Ajou University School of MedicineDepartment of Biochemistry and Molecular Biology, Ajou University School of MedicineDepartment of Chemistry and Nanoscience, Ewha Womans UniversityInstitute of Medical Science, Ajou University School of MedicineDepartment of Biochemistry and Molecular Biology, Ajou University School of MedicineDepartment of Biochemistry and Molecular Biology, Ajou University School of MedicineDepartment of Life Science, Ewha Womans UniversityDepartment of Physiology, Ajou University School of MedicineDivision of Cancer Cell Biology, The University of TokyoDepartment of Chemistry and Nanoscience, Ewha Womans UniversityDepartment of Biochemistry and Molecular Biology, Ajou University School of MedicineDuring cell division, chromosome alignment is engendered by connection of microtubules to kinetochores, coordinated by Aurora B and PLK1. Here, the authors show that the RSF1-PLK1 axis creates an activating phosphorylation on T236 in the GT motif of Aurora B and this is indispensable for Aurora B activation.https://doi.org/10.1038/s41467-021-26220-z |
| spellingShingle | Ho-Soo Lee Sunwoo Min Ye-Eun Jung Sunyoung Chae June Heo Jae-Ho Lee TaeSoo Kim Ho-Chul Kang Makoto Nakanish Sun-Shin Cha Hyeseong Cho Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms Nature Communications |
| title | Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms |
| title_full | Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms |
| title_fullStr | Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms |
| title_full_unstemmed | Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms |
| title_short | Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms |
| title_sort | spatiotemporal coordination of the rsf1 plk1 aurora b cascade establishes mitotic signaling platforms |
| url | https://doi.org/10.1038/s41467-021-26220-z |
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