Differential and Overlapping Effects of Melatonin and Its Metabolites on Keratinocyte Function: Bioinformatics and Metabolic Analyses

Differential and Overlapping Effects of Melatonin and Its Metabolites on Keratinocyte Function: Bioinformatics and Metabolic Analyses

We investigated the effects of melatonin and its selected metabolites, i.e., <i>N</i><sup>1</sup>-Acetyl-<i>N</i><sup>2</sup>-formyl-5-methoxykynurenamine (AFMK) and 6-hydroxymelatonin (6(OH)Mel), on cultured human epidermal keratinocytes (HEKs) to ass...

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Bibliographic Details
Main Authors: Joanna Stefan, Tae-Kang Kim, Fiona Schedel, Zorica Janjetovic, David K. Crossman, Kerstin Steinbrink, Radomir M. Slominski, Jaroslaw Zmijewski, Meri K. Tulic, Russel J. Reiter, Konrad Kleszczyński, Andrzej T. Slominski
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antioxidants
Subjects:
melatonin
metabolites of melatonin
RNA-<i>sequencing</i>
human keratinocytes
mitochondrial metabolism
Online Access:https://www.mdpi.com/2076-3921/10/4/618

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