Prognostic impact of uric acid in patients with acute decompensated heart failure
Aim. To evaluate the prognostic impact of serum uric acid (SUA) on clinical outcomes in patients with acute decompensated heart failure, as well as identify the correlation between hyperuricemia and renal function and diuretic resistance in these patients. Materials and methods. The study include...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2021-09-01
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| Series: | Терапевтический архив |
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| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/82973/63474 |
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| author | Svetlana N. Nasonova Anastasiya E. Lapteva Igor V. Zhirov Dzambolat R. Mindzaev Sergey N. Tereshchenko |
| author_facet | Svetlana N. Nasonova Anastasiya E. Lapteva Igor V. Zhirov Dzambolat R. Mindzaev Sergey N. Tereshchenko |
| author_sort | Svetlana N. Nasonova |
| collection | DOAJ |
| description | Aim. To evaluate the prognostic impact of serum uric acid (SUA) on clinical outcomes in patients with acute decompensated heart failure, as well as identify the correlation between hyperuricemia and renal function and diuretic resistance in these patients.
Materials and methods. The study included 175 patients (125 men and 50 women) with NYHA class IIIV acute decompensated heart failure. Median age was 64 (5675) years. The Information regarding the survival was obtained 3 years after the admission by telephone calls.
Results. 57 patients reached the end point (death from all causes); therefore, all patients were divided into groups: "alive", "dead". The SUA levels did not differ in the groups. The only significant difference in the studied parameters was the estimated glomerular filtration rate (eGFR), which was significantly higher in the "alive" group [70.5 (52.894) and 56 (4079), respectively; p=0.006]. A moderate negative correlation was found between SUA levels and eGFR in the correlation analysis (r=-0.313, p0.001). A comparative analysis showed, that SUA level on admission was significantly higher in patients who subsequently received increased doses of diuretics than in patients with a satisfactory response to standard doses of diuretics [567.8 (479.6791.9) and 512 (422.4619.4), respectively; p=0.011]. Also, higher eGFR level on admission was observed in patients from the normal SUA level group than in patients from the hyperuricemia group [94 (74.5101.5) and 63 (48.881.3), respectively; p=0.002].
Conclusion. We found no significant differences in the uric acid level in patients who reached the end point and those who did not reach it during the three-year follow-up. However, the found correlation between uric acid levels and diuretic resistance calls for further research. |
| first_indexed | 2024-12-13T00:22:02Z |
| format | Article |
| id | doaj.art-8549d96dab044e4d8df1b00d35151053 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T00:22:02Z |
| publishDate | 2021-09-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-8549d96dab044e4d8df1b00d351510532022-12-22T00:05:33Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422021-09-019391066107210.26442/00403660.2021.09.20103376233Prognostic impact of uric acid in patients with acute decompensated heart failureSvetlana N. Nasonova0https://orcid.org/0000-0002-0920-7417Anastasiya E. Lapteva1https://orcid.org/0000-0002-9260-9520Igor V. Zhirov2https://orcid.org/0000-0002-4066-2661Dzambolat R. Mindzaev3https://orcid.org/0000-0002-2236-3959Sergey N. Tereshchenko4https://orcid.org/0000-0001-9234-6129National Medical Research Center of CardiologyNational Medical Research Center of CardiologyNational Medical Research Center of CardiologyNational Medical Research Center of CardiologyNational Medical Research Center of CardiologyAim. To evaluate the prognostic impact of serum uric acid (SUA) on clinical outcomes in patients with acute decompensated heart failure, as well as identify the correlation between hyperuricemia and renal function and diuretic resistance in these patients. Materials and methods. The study included 175 patients (125 men and 50 women) with NYHA class IIIV acute decompensated heart failure. Median age was 64 (5675) years. The Information regarding the survival was obtained 3 years after the admission by telephone calls. Results. 57 patients reached the end point (death from all causes); therefore, all patients were divided into groups: "alive", "dead". The SUA levels did not differ in the groups. The only significant difference in the studied parameters was the estimated glomerular filtration rate (eGFR), which was significantly higher in the "alive" group [70.5 (52.894) and 56 (4079), respectively; p=0.006]. A moderate negative correlation was found between SUA levels and eGFR in the correlation analysis (r=-0.313, p0.001). A comparative analysis showed, that SUA level on admission was significantly higher in patients who subsequently received increased doses of diuretics than in patients with a satisfactory response to standard doses of diuretics [567.8 (479.6791.9) and 512 (422.4619.4), respectively; p=0.011]. Also, higher eGFR level on admission was observed in patients from the normal SUA level group than in patients from the hyperuricemia group [94 (74.5101.5) and 63 (48.881.3), respectively; p=0.002]. Conclusion. We found no significant differences in the uric acid level in patients who reached the end point and those who did not reach it during the three-year follow-up. However, the found correlation between uric acid levels and diuretic resistance calls for further research.https://ter-arkhiv.ru/0040-3660/article/viewFile/82973/63474acute decompensated heart failurehyperuricemiaserumuric aciddiuretic therapy |
| spellingShingle | Svetlana N. Nasonova Anastasiya E. Lapteva Igor V. Zhirov Dzambolat R. Mindzaev Sergey N. Tereshchenko Prognostic impact of uric acid in patients with acute decompensated heart failure Терапевтический архив acute decompensated heart failure hyperuricemia serumuric acid diuretic therapy |
| title | Prognostic impact of uric acid in patients with acute decompensated heart failure |
| title_full | Prognostic impact of uric acid in patients with acute decompensated heart failure |
| title_fullStr | Prognostic impact of uric acid in patients with acute decompensated heart failure |
| title_full_unstemmed | Prognostic impact of uric acid in patients with acute decompensated heart failure |
| title_short | Prognostic impact of uric acid in patients with acute decompensated heart failure |
| title_sort | prognostic impact of uric acid in patients with acute decompensated heart failure |
| topic | acute decompensated heart failure hyperuricemia serumuric acid diuretic therapy |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/82973/63474 |
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