Design and Evaluation of TIM-3-CD28 Checkpoint Fusion Proteins to Improve Anti-CD19 CAR T-Cell Function

Design and Evaluation of TIM-3-CD28 Checkpoint Fusion Proteins to Improve Anti-CD19 CAR T-Cell Function

Therapeutic targeting of inhibitory checkpoint molecules in combination with chimeric antigen receptor (CAR) T cells is currently investigated in a variety of clinical studies for treatment of hematologic and solid malignancies. However, the impact of co-inhibitory axes and their therapeutic implica...

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Bibliographic Details
Main Authors:	Franziska Blaeschke, Eva Ortner, Dana Stenger, Jasmin Mahdawi, Antonia Apfelbeck, Nicola Habjan, Tanja Weißer, Theresa Kaeuferle, Semjon Willier, Sebastian Kobold, Tobias Feuchtinger
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Series:	Frontiers in Immunology
Subjects:	CAR T cells checkpoint fusion proteins pediatric leukemia acute lymphoblastic leukemia (ALL) TIM-3 CD19
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.845499/full

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