GERD-related chronic cough: Possible mechanism, diagnosis and treatment
GERD, or gastroesophageal reflux disease, is a prevalent medical condition that affects millions of individuals throughout the world. Chronic cough is often caused by GERD, and chronic cough caused by GER is defined as GERD-related chronic cough (GERC). It is still unclear what the underlying molecu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1005404/full |
| _version_ | 1811340667355398144 |
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| author | Jiankang Wu Yiming Ma Yan Chen |
| author_facet | Jiankang Wu Yiming Ma Yan Chen |
| author_sort | Jiankang Wu |
| collection | DOAJ |
| description | GERD, or gastroesophageal reflux disease, is a prevalent medical condition that affects millions of individuals throughout the world. Chronic cough is often caused by GERD, and chronic cough caused by GER is defined as GERD-related chronic cough (GERC). It is still unclear what the underlying molecular mechanism behind GERC is. Reflux theory, reflex theory, airway allergies, and the novel mechanism of esophageal motility disorders are all assumed to be linked to GERC. Multichannel intraluminal impedance combined with pH monitoring remains the gold standard for the diagnosis of GERC, but is not well tolerated by patients due to its invasive nature. Recent discoveries of new impedance markers and new techniques (mucosal impedance testing, salivary pepsin, real-time MRI and narrow band imaging) show promises in the diagnosis of GERD, but the role in GERC needs further investigation. Advances in pharmacological treatment include potassium-competitive acid blockers and neuromodulators (such as Baclofen and Gabapentin), prokinetics and herbal medicines, as well as non-pharmacological treatments (such as lifestyle changes and respiratory exercises). More options have been provided for the treatment of GERC other than acid suppression therapy and anti-reflux surgery. In this review, we attempt to review recent advances in GERC mechanism, diagnosis, and subsequent treatment options, so as to provide guidance for management of GERC. |
| first_indexed | 2024-04-13T18:45:20Z |
| format | Article |
| id | doaj.art-854cc8ea86524639a064f28f68c8f90a |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T18:45:20Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-854cc8ea86524639a064f28f68c8f90a2022-12-22T02:34:36ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-10-011310.3389/fphys.2022.10054041005404GERD-related chronic cough: Possible mechanism, diagnosis and treatmentJiankang WuYiming MaYan ChenGERD, or gastroesophageal reflux disease, is a prevalent medical condition that affects millions of individuals throughout the world. Chronic cough is often caused by GERD, and chronic cough caused by GER is defined as GERD-related chronic cough (GERC). It is still unclear what the underlying molecular mechanism behind GERC is. Reflux theory, reflex theory, airway allergies, and the novel mechanism of esophageal motility disorders are all assumed to be linked to GERC. Multichannel intraluminal impedance combined with pH monitoring remains the gold standard for the diagnosis of GERC, but is not well tolerated by patients due to its invasive nature. Recent discoveries of new impedance markers and new techniques (mucosal impedance testing, salivary pepsin, real-time MRI and narrow band imaging) show promises in the diagnosis of GERD, but the role in GERC needs further investigation. Advances in pharmacological treatment include potassium-competitive acid blockers and neuromodulators (such as Baclofen and Gabapentin), prokinetics and herbal medicines, as well as non-pharmacological treatments (such as lifestyle changes and respiratory exercises). More options have been provided for the treatment of GERC other than acid suppression therapy and anti-reflux surgery. In this review, we attempt to review recent advances in GERC mechanism, diagnosis, and subsequent treatment options, so as to provide guidance for management of GERC.https://www.frontiersin.org/articles/10.3389/fphys.2022.1005404/fullgastroesophageal reflux diseasechronic coughmechanismdiagnosistreatment |
| spellingShingle | Jiankang Wu Yiming Ma Yan Chen GERD-related chronic cough: Possible mechanism, diagnosis and treatment Frontiers in Physiology gastroesophageal reflux disease chronic cough mechanism diagnosis treatment |
| title | GERD-related chronic cough: Possible mechanism, diagnosis and treatment |
| title_full | GERD-related chronic cough: Possible mechanism, diagnosis and treatment |
| title_fullStr | GERD-related chronic cough: Possible mechanism, diagnosis and treatment |
| title_full_unstemmed | GERD-related chronic cough: Possible mechanism, diagnosis and treatment |
| title_short | GERD-related chronic cough: Possible mechanism, diagnosis and treatment |
| title_sort | gerd related chronic cough possible mechanism diagnosis and treatment |
| topic | gastroesophageal reflux disease chronic cough mechanism diagnosis treatment |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1005404/full |
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