An Isoflavone from Dipteryx alata Vogel is Active against the in Vitro Neuromuscular Paralysis of Bothrops jararacussu Snake Venom and Bothropstoxin I, and Prevents Venom-Induced Myonecrosis

An Isoflavone from Dipteryx alata Vogel is Active against the in Vitro Neuromuscular Paralysis of Bothrops jararacussu Snake Venom and Bothropstoxin I, and Prevents Venom-Induced Myonecrosis

Snakebite is a neglected disease and serious health problem in Brazil, with most bites being caused by snakes of the genus Bothrops. Although serum therapy is the primary treatment for systemic envenomation, it is generally ineffective in neutralizing the local effects of these venoms. In this work,...

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Bibliographic Details
Main Authors: Miriéle C. Ferraz, Edson H. Yoshida, Renata V.S. Tavares, José C. Cogo, Adélia C.O. Cintra, Cháriston A. Dal Belo, Luiz M. Franco, Márcio G. dos Santos, Flávia A. Resende, Eliana A. Varanda, Stephen Hyslop, Pilar Puebla, Arturo San Feliciano, Yoko Oshima-Franco
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Molecules
Subjects:
ames test
bothropstoxin-I
7,8,3'-trihydroxy-4'-methoxyisoflavone
neuromuscular junction
Salmonella mutagenicity
snake venoms
Online Access:http://www.mdpi.com/1420-3049/19/5/5790

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