Alcohol use is associated with affective and interoceptive network alterations in bipolar disorder
Abstract Introduction Alcohol use in bipolar disorder (BD) is associated with mood lability and negative illness trajectory, while also impacting functional networks related to emotion, cognition, and introspection. The adverse impact of alcohol use in BD may be explained by its additive effects on...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2832 |
| _version_ | 1797893710922383360 |
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| author | Fiona M. Martyn Genevieve McPhilemy Leila Nabulsi Jacqueline Quirke Brian Hallahan Colm McDonald Dara M. Cannon |
| author_facet | Fiona M. Martyn Genevieve McPhilemy Leila Nabulsi Jacqueline Quirke Brian Hallahan Colm McDonald Dara M. Cannon |
| author_sort | Fiona M. Martyn |
| collection | DOAJ |
| description | Abstract Introduction Alcohol use in bipolar disorder (BD) is associated with mood lability and negative illness trajectory, while also impacting functional networks related to emotion, cognition, and introspection. The adverse impact of alcohol use in BD may be explained by its additive effects on these networks, thereby contributing to a poorer clinical outcome. Methods Forty BD‐I (DSM‐IV‐TR) and 46 psychiatrically healthy controls underwent T1 and resting state functional MRI scanning and the Alcohol Use Disorders Identification Test‐Consumption (AUDIT‐C) to assess alcohol use. Functional images were decomposed using spatial independent component analysis into 14 resting state networks (RSN), which were examined for effect of alcohol use and diagnosis‐by‐alcohol use accounting for age, sex, and diagnosis. Results Despite the groups consuming similar amounts of alcohol (BD: mean score ± SD 3.63 ± 3; HC 4.72 ± 3, U = 713, p = .07), for BD participants, greater alcohol use was associated with increased connectivity of the paracingulate gyrus within a default mode network (DMN) and reduced connectivity within an executive control network (ECN) relative to controls. Independently, greater alcohol use was associated with increased connectivity within an ECN and reduced connectivity within a DMN. A diagnosis of BD was associated with increased connectivity of a DMN and reduced connectivity of an ECN. Conclusion Affective symptomatology in BD is suggested to arise from the aberrant functionality of networks subserving emotive, cognitive, and introspective processes. Taken together, our results suggest that during euthymic periods, alcohol can contribute to the weakening of emotional regulation and response, potentially explaining the increased lability of mood and vulnerability to relapse within the disorder. |
| first_indexed | 2024-04-10T06:57:15Z |
| format | Article |
| id | doaj.art-854d6b8639514c8d9ff7209681baf479 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-04-10T06:57:15Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-854d6b8639514c8d9ff7209681baf4792023-02-28T07:01:06ZengWileyBrain and Behavior2162-32792023-01-01131n/an/a10.1002/brb3.2832Alcohol use is associated with affective and interoceptive network alterations in bipolar disorderFiona M. Martyn0Genevieve McPhilemy1Leila Nabulsi2Jacqueline Quirke3Brian Hallahan4Colm McDonald5Dara M. Cannon6Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Lab, NCBES Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Galway H91 TK33 IrelandCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Lab, NCBES Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Galway H91 TK33 IrelandCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Lab, NCBES Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Galway H91 TK33 IrelandCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Lab, NCBES Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Galway H91 TK33 IrelandCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Lab, NCBES Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Galway H91 TK33 IrelandCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Lab, NCBES Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Galway H91 TK33 IrelandCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Lab, NCBES Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences National University of Ireland Galway Galway Galway H91 TK33 IrelandAbstract Introduction Alcohol use in bipolar disorder (BD) is associated with mood lability and negative illness trajectory, while also impacting functional networks related to emotion, cognition, and introspection. The adverse impact of alcohol use in BD may be explained by its additive effects on these networks, thereby contributing to a poorer clinical outcome. Methods Forty BD‐I (DSM‐IV‐TR) and 46 psychiatrically healthy controls underwent T1 and resting state functional MRI scanning and the Alcohol Use Disorders Identification Test‐Consumption (AUDIT‐C) to assess alcohol use. Functional images were decomposed using spatial independent component analysis into 14 resting state networks (RSN), which were examined for effect of alcohol use and diagnosis‐by‐alcohol use accounting for age, sex, and diagnosis. Results Despite the groups consuming similar amounts of alcohol (BD: mean score ± SD 3.63 ± 3; HC 4.72 ± 3, U = 713, p = .07), for BD participants, greater alcohol use was associated with increased connectivity of the paracingulate gyrus within a default mode network (DMN) and reduced connectivity within an executive control network (ECN) relative to controls. Independently, greater alcohol use was associated with increased connectivity within an ECN and reduced connectivity within a DMN. A diagnosis of BD was associated with increased connectivity of a DMN and reduced connectivity of an ECN. Conclusion Affective symptomatology in BD is suggested to arise from the aberrant functionality of networks subserving emotive, cognitive, and introspective processes. Taken together, our results suggest that during euthymic periods, alcohol can contribute to the weakening of emotional regulation and response, potentially explaining the increased lability of mood and vulnerability to relapse within the disorder.https://doi.org/10.1002/brb3.2832alcohol usebipolar disorderdefault mode networkexecutive control networkfunctional connectivity |
| spellingShingle | Fiona M. Martyn Genevieve McPhilemy Leila Nabulsi Jacqueline Quirke Brian Hallahan Colm McDonald Dara M. Cannon Alcohol use is associated with affective and interoceptive network alterations in bipolar disorder Brain and Behavior alcohol use bipolar disorder default mode network executive control network functional connectivity |
| title | Alcohol use is associated with affective and interoceptive network alterations in bipolar disorder |
| title_full | Alcohol use is associated with affective and interoceptive network alterations in bipolar disorder |
| title_fullStr | Alcohol use is associated with affective and interoceptive network alterations in bipolar disorder |
| title_full_unstemmed | Alcohol use is associated with affective and interoceptive network alterations in bipolar disorder |
| title_short | Alcohol use is associated with affective and interoceptive network alterations in bipolar disorder |
| title_sort | alcohol use is associated with affective and interoceptive network alterations in bipolar disorder |
| topic | alcohol use bipolar disorder default mode network executive control network functional connectivity |
| url | https://doi.org/10.1002/brb3.2832 |
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