Cytochalasans from the Endophytic Fungus <i>Phomopsis</i> sp. shj2 and Their Antimigratory Activities
Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus <i>Phomopsis</i> sp. shj2 exhibited an antimigratory effect. Further chemical investigation on <i>Phomopsis</i> sp. shj2 has le...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/8/5/543 |
| Summary: | Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus <i>Phomopsis</i> sp. shj2 exhibited an antimigratory effect. Further chemical investigation on <i>Phomopsis</i> sp. shj2 has led to the discovery of seven new cytochalasans (<b>1</b>–<b>7</b>), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds <b>1</b>–<b>3</b> and <b>8</b>–<b>11</b> exhibited antimigratory effects against MDA-MB-231 in vitro with IC<sub>50</sub> values in the range of 1.01−10.42 μM. |
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| ISSN: | 2309-608X |