Cytochalasans from the Endophytic Fungus <i>Phomopsis</i> sp. shj2 and Their Antimigratory Activities
Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus <i>Phomopsis</i> sp. shj2 exhibited an antimigratory effect. Further chemical investigation on <i>Phomopsis</i> sp. shj2 has le...
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MDPI AG
2022-05-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/5/543 |
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| author | Bing-Chao Yan Wei-Guang Wang Ling-Mei Kong Jian-Wei Tang Xue Du Yan Li Pema-Tenzin Puno |
| author_facet | Bing-Chao Yan Wei-Guang Wang Ling-Mei Kong Jian-Wei Tang Xue Du Yan Li Pema-Tenzin Puno |
| author_sort | Bing-Chao Yan |
| collection | DOAJ |
| description | Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus <i>Phomopsis</i> sp. shj2 exhibited an antimigratory effect. Further chemical investigation on <i>Phomopsis</i> sp. shj2 has led to the discovery of seven new cytochalasans (<b>1</b>–<b>7</b>), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds <b>1</b>–<b>3</b> and <b>8</b>–<b>11</b> exhibited antimigratory effects against MDA-MB-231 in vitro with IC<sub>50</sub> values in the range of 1.01−10.42 μM. |
| first_indexed | 2024-03-10T03:36:47Z |
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| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T03:36:47Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
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| series | Journal of Fungi |
| spelling | doaj.art-8550758b2ec84aea8873d04ed09fce072023-11-23T11:42:38ZengMDPI AGJournal of Fungi2309-608X2022-05-018554310.3390/jof8050543Cytochalasans from the Endophytic Fungus <i>Phomopsis</i> sp. shj2 and Their Antimigratory ActivitiesBing-Chao Yan0Wei-Guang Wang1Ling-Mei Kong2Jian-Wei Tang3Xue Du4Yan Li5Pema-Tenzin Puno6State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaCytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus <i>Phomopsis</i> sp. shj2 exhibited an antimigratory effect. Further chemical investigation on <i>Phomopsis</i> sp. shj2 has led to the discovery of seven new cytochalasans (<b>1</b>–<b>7</b>), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds <b>1</b>–<b>3</b> and <b>8</b>–<b>11</b> exhibited antimigratory effects against MDA-MB-231 in vitro with IC<sub>50</sub> values in the range of 1.01−10.42 μM.https://www.mdpi.com/2309-608X/8/5/543endophytic fungus<i>Phomopsis</i>cytochalasanantimigratory activity |
| spellingShingle | Bing-Chao Yan Wei-Guang Wang Ling-Mei Kong Jian-Wei Tang Xue Du Yan Li Pema-Tenzin Puno Cytochalasans from the Endophytic Fungus <i>Phomopsis</i> sp. shj2 and Their Antimigratory Activities Journal of Fungi endophytic fungus <i>Phomopsis</i> cytochalasan antimigratory activity |
| title | Cytochalasans from the Endophytic Fungus <i>Phomopsis</i> sp. shj2 and Their Antimigratory Activities |
| title_full | Cytochalasans from the Endophytic Fungus <i>Phomopsis</i> sp. shj2 and Their Antimigratory Activities |
| title_fullStr | Cytochalasans from the Endophytic Fungus <i>Phomopsis</i> sp. shj2 and Their Antimigratory Activities |
| title_full_unstemmed | Cytochalasans from the Endophytic Fungus <i>Phomopsis</i> sp. shj2 and Their Antimigratory Activities |
| title_short | Cytochalasans from the Endophytic Fungus <i>Phomopsis</i> sp. shj2 and Their Antimigratory Activities |
| title_sort | cytochalasans from the endophytic fungus i phomopsis i sp shj2 and their antimigratory activities |
| topic | endophytic fungus <i>Phomopsis</i> cytochalasan antimigratory activity |
| url | https://www.mdpi.com/2309-608X/8/5/543 |
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