Relationship Between ADPKD and Post-Renal Transplant Diabetes Mellitus
Background: Autosomal-dominant polycystic kidney disease (ADPKD), a common hereditary disease, is characterized by the progressive development and enlargement of multiple cysts in both kidneys, and typically resulting in end stage renal disease (ESRD) by the fifth decade of life. Post-transplant dia...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2006-08-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3083.pdf&manuscript_id=3083 |
| _version_ | 1819058553531400192 |
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| author | S. Seifi A. Soleimani M. Lesan Pezeshki B. Einollahi M.R. Khatami M. M Mazdeh F.L Ahmadi S. Maziyar |
| author_facet | S. Seifi A. Soleimani M. Lesan Pezeshki B. Einollahi M.R. Khatami M. M Mazdeh F.L Ahmadi S. Maziyar |
| author_sort | S. Seifi |
| collection | DOAJ |
| description | Background: Autosomal-dominant polycystic kidney disease (ADPKD), a common hereditary disease, is characterized by the progressive development and enlargement of multiple cysts in both kidneys, and typically resulting in end stage renal disease (ESRD) by the fifth decade of life. Post-transplant diabetes mellitus (PTDM), a common complication after transplantation with an incidence rate of 2.5-20%, is associated with poor graft and patient survival. In few studies, PTDM has been more frequent in ADPKD transplanted patients. In the present study, we investigated whether there is any association between PTDM and ADPKD in our patients. Methods: In this prospective study, 140 non-diabetic and nonsmoker successfully transplanted patients (27 ADPKD and 113 non ADPKD patients) were enrolled during three years. Both groups were matched for age, sex, body mass index (BMI), duration of renal replacement therapy before transplantation and also immunosuppressive protocols after transplant. Post-transplant diabetes mellitus was defined as Clinical Practice Guidelines advocated by Canadian Diabetes Association. All patients were followed for 12 months. Results: PTDM occurred in 11.1% of ADPKD patients and in 13.1% of control group which was statistically insignificant (P > 0.05). The development of PTDM in ADPKD group was not related to sex, age, and hypertension, duration of renal replacement therapy before transplantation, BMI and serum creatinine levels (P > 0.05). Conclusion: Post-transplant diabetes mellitus appears not to be associated with autosomal-dominant polycystic kidney disease as an etiology of end stage renal disease. |
| first_indexed | 2024-12-21T13:57:02Z |
| format | Article |
| id | doaj.art-855595f4947847579ab8c1e21281c0e4 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-21T13:57:02Z |
| publishDate | 2006-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-855595f4947847579ab8c1e21281c0e42022-12-21T19:01:30ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222006-08-016486873Relationship Between ADPKD and Post-Renal Transplant Diabetes MellitusS. SeifiA. SoleimaniM. Lesan PezeshkiB. EinollahiM.R. KhatamiM. M MazdehF.L AhmadiS. MaziyarBackground: Autosomal-dominant polycystic kidney disease (ADPKD), a common hereditary disease, is characterized by the progressive development and enlargement of multiple cysts in both kidneys, and typically resulting in end stage renal disease (ESRD) by the fifth decade of life. Post-transplant diabetes mellitus (PTDM), a common complication after transplantation with an incidence rate of 2.5-20%, is associated with poor graft and patient survival. In few studies, PTDM has been more frequent in ADPKD transplanted patients. In the present study, we investigated whether there is any association between PTDM and ADPKD in our patients. Methods: In this prospective study, 140 non-diabetic and nonsmoker successfully transplanted patients (27 ADPKD and 113 non ADPKD patients) were enrolled during three years. Both groups were matched for age, sex, body mass index (BMI), duration of renal replacement therapy before transplantation and also immunosuppressive protocols after transplant. Post-transplant diabetes mellitus was defined as Clinical Practice Guidelines advocated by Canadian Diabetes Association. All patients were followed for 12 months. Results: PTDM occurred in 11.1% of ADPKD patients and in 13.1% of control group which was statistically insignificant (P > 0.05). The development of PTDM in ADPKD group was not related to sex, age, and hypertension, duration of renal replacement therapy before transplantation, BMI and serum creatinine levels (P > 0.05). Conclusion: Post-transplant diabetes mellitus appears not to be associated with autosomal-dominant polycystic kidney disease as an etiology of end stage renal disease.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3083.pdf&manuscript_id=3083PTDM |
| spellingShingle | S. Seifi A. Soleimani M. Lesan Pezeshki B. Einollahi M.R. Khatami M. M Mazdeh F.L Ahmadi S. Maziyar Relationship Between ADPKD and Post-Renal Transplant Diabetes Mellitus Tehran University Medical Journal PTDM |
| title | Relationship Between ADPKD and Post-Renal Transplant Diabetes Mellitus |
| title_full | Relationship Between ADPKD and Post-Renal Transplant Diabetes Mellitus |
| title_fullStr | Relationship Between ADPKD and Post-Renal Transplant Diabetes Mellitus |
| title_full_unstemmed | Relationship Between ADPKD and Post-Renal Transplant Diabetes Mellitus |
| title_short | Relationship Between ADPKD and Post-Renal Transplant Diabetes Mellitus |
| title_sort | relationship between adpkd and post renal transplant diabetes mellitus |
| topic | PTDM |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3083.pdf&manuscript_id=3083 |
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