Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort
Abstract Background The role of systemic inflammation in promoting cardiovascular diseases has attracted attention, but its correlation with various arrhythmias remains to be clarified. We aimed to comprehensively assess the association between various indicators of systemic inflammation and atrial...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Medicine |
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| Online Access: | https://doi.org/10.1186/s12916-023-02770-5 |
| _version_ | 1797864502197223424 |
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| author | Xiaorong Yang Shaohua Zhao Shaohua Wang Xuelei Cao Yue Xu Meichen Yan Mingmin Pang Fan Yi Hao Wang |
| author_facet | Xiaorong Yang Shaohua Zhao Shaohua Wang Xuelei Cao Yue Xu Meichen Yan Mingmin Pang Fan Yi Hao Wang |
| author_sort | Xiaorong Yang |
| collection | DOAJ |
| description | Abstract Background The role of systemic inflammation in promoting cardiovascular diseases has attracted attention, but its correlation with various arrhythmias remains to be clarified. We aimed to comprehensively assess the association between various indicators of systemic inflammation and atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), and bradyarrhythmia in the UK Biobank cohort. Methods After excluding ineligible participants, a total of 478,524 eligible individuals (46.75% male, aged 40–69 years) were enrolled in the study to assess the association between systemic inflammatory indicators and each type of arrhythmia. Results After covariates were fully adjusted, CRP levels were found to have an essentially linear positive correlation with the risk of various arrhythmias; neutrophil count, monocyte count, and NLR showed a non-linear positive correlation; and lymphocyte count, SII, PLR, and LMR showed a U-shaped association. VA showed the strongest association with systemic inflammation indicators, and it was followed sequentially by AF and bradyarrhythmia. Conclusions Multiple systemic inflammatory indicators showed strong associations with the onset of AF, VA, and bradyarrhythmia, of which the latter two have been rarely studied. Active systemic inflammation management might have favorable effects in reducing the arrhythmia burden and further randomized controlled studies are needed. |
| first_indexed | 2024-04-09T22:52:57Z |
| format | Article |
| id | doaj.art-85561413f97f421e89034bb31ffaaedd |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-04-09T22:52:57Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-85561413f97f421e89034bb31ffaaedd2023-03-22T11:32:43ZengBMCBMC Medicine1741-70152023-02-0121111310.1186/s12916-023-02770-5Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohortXiaorong Yang0Shaohua Zhao1Shaohua Wang2Xuelei Cao3Yue Xu4Meichen Yan5Mingmin Pang6Fan Yi7Hao Wang8Clinical Epidemiology Unit, Qilu Hospital of Shandong UniversityDepartment of Geriatric Medicine, Qilu Hospital of Shandong UniversityDepartment of Internal Medicine, Jinan HospitalDepartment of Clinical Laboratory, Qilu Hospital of Shandong UniversityQilu Hospital of Shandong UniversityQilu Hospital of Shandong UniversityQilu Hospital of Shandong UniversityDepartment of Pharmacology, School of Basic Medical Sciences, Shandong UniversityDepartment of Critical Care Medicine, Qilu Hospital of Shandong UniversityAbstract Background The role of systemic inflammation in promoting cardiovascular diseases has attracted attention, but its correlation with various arrhythmias remains to be clarified. We aimed to comprehensively assess the association between various indicators of systemic inflammation and atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), and bradyarrhythmia in the UK Biobank cohort. Methods After excluding ineligible participants, a total of 478,524 eligible individuals (46.75% male, aged 40–69 years) were enrolled in the study to assess the association between systemic inflammatory indicators and each type of arrhythmia. Results After covariates were fully adjusted, CRP levels were found to have an essentially linear positive correlation with the risk of various arrhythmias; neutrophil count, monocyte count, and NLR showed a non-linear positive correlation; and lymphocyte count, SII, PLR, and LMR showed a U-shaped association. VA showed the strongest association with systemic inflammation indicators, and it was followed sequentially by AF and bradyarrhythmia. Conclusions Multiple systemic inflammatory indicators showed strong associations with the onset of AF, VA, and bradyarrhythmia, of which the latter two have been rarely studied. Active systemic inflammation management might have favorable effects in reducing the arrhythmia burden and further randomized controlled studies are needed.https://doi.org/10.1186/s12916-023-02770-5Atrial fibrillationVentricular arrhythmiaBradyarrhythmiaSystemic inflammationBlood-based inflammation markersUK Biobank |
| spellingShingle | Xiaorong Yang Shaohua Zhao Shaohua Wang Xuelei Cao Yue Xu Meichen Yan Mingmin Pang Fan Yi Hao Wang Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort BMC Medicine Atrial fibrillation Ventricular arrhythmia Bradyarrhythmia Systemic inflammation Blood-based inflammation markers UK Biobank |
| title | Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort |
| title_full | Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort |
| title_fullStr | Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort |
| title_full_unstemmed | Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort |
| title_short | Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort |
| title_sort | systemic inflammation indicators and risk of incident arrhythmias in 478 524 individuals evidence from the uk biobank cohort |
| topic | Atrial fibrillation Ventricular arrhythmia Bradyarrhythmia Systemic inflammation Blood-based inflammation markers UK Biobank |
| url | https://doi.org/10.1186/s12916-023-02770-5 |
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