Novel Methods of Targeting IL-1 Signalling for the Treatment of Breast Cancer Bone Metastasis

Novel Methods of Targeting IL-1 Signalling for the Treatment of Breast Cancer Bone Metastasis

Breast cancer bone metastasis is currently incurable. Evidence suggests that inhibiting IL-1 signalling with the IL1R antagonist, Anakinra, or the IL1β antibody, Canakinumab, prevents metastasis and almost eliminates breast cancer growth in the bone. However, these drugs increase primary tumour grow...

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Bibliographic Details
Main Authors: Jiabao Zhou, Jennifer M. Down, Christopher N. George, Jessica Murphy, Diane V. Lefley, Claudia Tulotta, Marwa A. Alsharif, Michael Leach, Penelope D. Ottewell
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
breast cancer
bone metastasis
IL1β
mouse models
Online Access:https://www.mdpi.com/2072-6694/14/19/4816

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