Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis

Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis

Summary: Protein kinase B (AKT) is essential for cell survival, proliferation, and migration and has been associated with several diseases. Here, we demonstrate that inositol polyphosphate multikinase (IPMK’s) lipid kinase property drives AKT activation via increasing membrane localization and activ...

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Bibliographic Details
Main Authors: Luke Reilly, Evan R. Semenza, George Koshkaryan, Subrata Mishra, Sujan Chatterjee, Efrat Abramson, Pamela Mishra, Yoshitasu Sei, Stephen A. Wank, Mark Donowitz, Solomon H. Snyder, Prasun Guha
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Gastroenterology
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223007009

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