Carotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysis
Background/Aim. Vascular endothelium plays an important role in atherogenesis. The aim of this study was to estimate the correlation of endothelium malfunction and arteriosclerosis in patients on hemodialysis. Methods. The investigation was designed as a clinical, non-randomized, fiveyear study in t...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2010-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501011916S.pdf |
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| author | Stolić Radojica Trajković Goran Jovanović Aleksandar Stolić Dragica Perić Vladan Sovtić Saša Šubarić-Gorgieva Gordana |
| author_facet | Stolić Radojica Trajković Goran Jovanović Aleksandar Stolić Dragica Perić Vladan Sovtić Saša Šubarić-Gorgieva Gordana |
| author_sort | Stolić Radojica |
| collection | DOAJ |
| description | Background/Aim. Vascular endothelium plays an important role in atherogenesis. The aim of this study was to estimate the correlation of endothelium malfunction and arteriosclerosis in patients on hemodialysis. Methods. The investigation was designed as a clinical, non-randomized, fiveyear study in the 'Kragujevac' Clinical Center and included 146 patients. We evaluated demographic characteristics, smoking, duration of dialysis, existence of tissue calcification and duplex ultrasound parameters of the carotid artery. All lethal outcomes, including the cause and time of death were recorded. Results. The cumulative survival rate was 57.5%. Survival was short in patients with wider lumen diameter of the carotid arteries. Carotid artery lumen diameter in men was wider than in women. The area cross section was closely correlated with intima media thickness (r = 0.913; p < 0.0001), as well as with the lumen diameter of the carotid arteries (r = 0.527; p < 0.0001). Carotid artery lumen diameter was negatively associated with serum cholesterol (r = - 0.278; p = 0.019), while serum triglycerides correlated negatively with the cross section of intima media (r = -0.261; p = 0.028). Positive correlations were found between the serum total protein level and carotid artery lumen diameter (r = 0.235; p = 0.047), cross section intima media (r = 0.269; p = 0.022) and cholesterol (r = 0.248; p = 0.037). Time on dialysis showed a negative correlation with carotid artery cross section (r = -0.241; p = 0.04), while age was positively correlated with intima media (r = 0.295; p = 0.013), lumen diameter (r = 0.296; p = 0.012) and intima media cross section (r = 0.347; p = 0.003). Regression analysis pointed to predictive importance of carotid artery lumen diameter for survival (Beta = 0.437; p = 0.011) of the examined patients. The cumulative rate of survival was 57%. Conclusion. In our study patient age correlated positively with all parameters of arteriosclerosis. The average duration of dialysis was negatively associated with carotid artery diameter, which was significantly higher in males. Regression correlation analyses indicated that the survival rate of the patients on hemodialysis was lower if the carotid artery diameter was larger. |
| first_indexed | 2024-12-11T03:33:42Z |
| format | Article |
| id | doaj.art-855817e04208458daba50987924a3324 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-11T03:33:42Z |
| publishDate | 2010-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-855817e04208458daba50987924a33242022-12-22T01:22:19ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502010-01-01671191692210.2298/VSP1011916SCarotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysisStolić RadojicaTrajković GoranJovanović AleksandarStolić DragicaPerić VladanSovtić SašaŠubarić-Gorgieva GordanaBackground/Aim. Vascular endothelium plays an important role in atherogenesis. The aim of this study was to estimate the correlation of endothelium malfunction and arteriosclerosis in patients on hemodialysis. Methods. The investigation was designed as a clinical, non-randomized, fiveyear study in the 'Kragujevac' Clinical Center and included 146 patients. We evaluated demographic characteristics, smoking, duration of dialysis, existence of tissue calcification and duplex ultrasound parameters of the carotid artery. All lethal outcomes, including the cause and time of death were recorded. Results. The cumulative survival rate was 57.5%. Survival was short in patients with wider lumen diameter of the carotid arteries. Carotid artery lumen diameter in men was wider than in women. The area cross section was closely correlated with intima media thickness (r = 0.913; p < 0.0001), as well as with the lumen diameter of the carotid arteries (r = 0.527; p < 0.0001). Carotid artery lumen diameter was negatively associated with serum cholesterol (r = - 0.278; p = 0.019), while serum triglycerides correlated negatively with the cross section of intima media (r = -0.261; p = 0.028). Positive correlations were found between the serum total protein level and carotid artery lumen diameter (r = 0.235; p = 0.047), cross section intima media (r = 0.269; p = 0.022) and cholesterol (r = 0.248; p = 0.037). Time on dialysis showed a negative correlation with carotid artery cross section (r = -0.241; p = 0.04), while age was positively correlated with intima media (r = 0.295; p = 0.013), lumen diameter (r = 0.296; p = 0.012) and intima media cross section (r = 0.347; p = 0.003). Regression analysis pointed to predictive importance of carotid artery lumen diameter for survival (Beta = 0.437; p = 0.011) of the examined patients. The cumulative rate of survival was 57%. Conclusion. In our study patient age correlated positively with all parameters of arteriosclerosis. The average duration of dialysis was negatively associated with carotid artery diameter, which was significantly higher in males. Regression correlation analyses indicated that the survival rate of the patients on hemodialysis was lower if the carotid artery diameter was larger.http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501011916S.pdfarteriosclerosishemodialysisendothelium, vascularultrasonographymortalitycarotid artery, common |
| spellingShingle | Stolić Radojica Trajković Goran Jovanović Aleksandar Stolić Dragica Perić Vladan Sovtić Saša Šubarić-Gorgieva Gordana Carotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysis Vojnosanitetski Pregled arteriosclerosis hemodialysis endothelium, vascular ultrasonography mortality carotid artery, common |
| title | Carotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysis |
| title_full | Carotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysis |
| title_fullStr | Carotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysis |
| title_full_unstemmed | Carotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysis |
| title_short | Carotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysis |
| title_sort | carotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysis |
| topic | arteriosclerosis hemodialysis endothelium, vascular ultrasonography mortality carotid artery, common |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501011916S.pdf |
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