Caffeine combined with taurine improves cognitive function and locomotor performance in sleep-deprived mice
Sleep deprivation negatively influences cognitive function and locomotor performance. In this study, a sleep-deprived mice model was used to evaluate the protective effects of caffeine combined with taurine (C&T, 4.35, 8.70, 13.05 g/kg) on fatigue and the underlying mechanisms, showing that a hi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622003681 |
| _version_ | 1828275610610302976 |
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| author | Peng Du Changhui Du Ruoyong Wang Hongkang Zhu Hanyi Hua Yuliang Cheng Yahui Guo He Qian |
| author_facet | Peng Du Changhui Du Ruoyong Wang Hongkang Zhu Hanyi Hua Yuliang Cheng Yahui Guo He Qian |
| author_sort | Peng Du |
| collection | DOAJ |
| description | Sleep deprivation negatively influences cognitive function and locomotor performance. In this study, a sleep-deprived mice model was used to evaluate the protective effects of caffeine combined with taurine (C&T, 4.35, 8.70, 13.05 g/kg) on fatigue and the underlying mechanisms, showing that a high concentration of combined caffeine and taurine significantly increased the movement speed in the open field by 47 % (3.69 vs 5.42 cm/s, P < 0.05) and in the Y maze (3.31 vs 6.40 cm/s, P < 0.01). Combined caffeine and taurine improved the cognitive deficits and locomotor imbalance caused by sleep deprivation. Additionally, after weight-loaded swimming test, the caffeine and taurine-treated mice had increased glycogen content and antioxidant enzyme activity and significantly reduced serum inflammatory factors indicating that the mechanism may involve reducing oxidative stress and inflammation. In conclusion, combined caffeine and taurine may be a potential treatment for preventing and improving fatigue. |
| first_indexed | 2024-04-13T06:48:28Z |
| format | Article |
| id | doaj.art-8558329f3e844ce492570133ec6b20fe |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-13T06:48:28Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8558329f3e844ce492570133ec6b20fe2022-12-22T02:57:28ZengElsevierJournal of Functional Foods1756-46462022-12-0199105298Caffeine combined with taurine improves cognitive function and locomotor performance in sleep-deprived micePeng Du0Changhui Du1Ruoyong Wang2Hongkang Zhu3Hanyi Hua4Yuliang Cheng5Yahui Guo6He Qian7Air Force Medical Center, Beijing 100142. ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaAir Force Medical Center, Beijing 100142. ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Corresponding author.Sleep deprivation negatively influences cognitive function and locomotor performance. In this study, a sleep-deprived mice model was used to evaluate the protective effects of caffeine combined with taurine (C&T, 4.35, 8.70, 13.05 g/kg) on fatigue and the underlying mechanisms, showing that a high concentration of combined caffeine and taurine significantly increased the movement speed in the open field by 47 % (3.69 vs 5.42 cm/s, P < 0.05) and in the Y maze (3.31 vs 6.40 cm/s, P < 0.01). Combined caffeine and taurine improved the cognitive deficits and locomotor imbalance caused by sleep deprivation. Additionally, after weight-loaded swimming test, the caffeine and taurine-treated mice had increased glycogen content and antioxidant enzyme activity and significantly reduced serum inflammatory factors indicating that the mechanism may involve reducing oxidative stress and inflammation. In conclusion, combined caffeine and taurine may be a potential treatment for preventing and improving fatigue.http://www.sciencedirect.com/science/article/pii/S1756464622003681CaffeineTaurineSleep deprivationAnti-fatigueCognitive and locomotor function |
| spellingShingle | Peng Du Changhui Du Ruoyong Wang Hongkang Zhu Hanyi Hua Yuliang Cheng Yahui Guo He Qian Caffeine combined with taurine improves cognitive function and locomotor performance in sleep-deprived mice Journal of Functional Foods Caffeine Taurine Sleep deprivation Anti-fatigue Cognitive and locomotor function |
| title | Caffeine combined with taurine improves cognitive function and locomotor performance in sleep-deprived mice |
| title_full | Caffeine combined with taurine improves cognitive function and locomotor performance in sleep-deprived mice |
| title_fullStr | Caffeine combined with taurine improves cognitive function and locomotor performance in sleep-deprived mice |
| title_full_unstemmed | Caffeine combined with taurine improves cognitive function and locomotor performance in sleep-deprived mice |
| title_short | Caffeine combined with taurine improves cognitive function and locomotor performance in sleep-deprived mice |
| title_sort | caffeine combined with taurine improves cognitive function and locomotor performance in sleep deprived mice |
| topic | Caffeine Taurine Sleep deprivation Anti-fatigue Cognitive and locomotor function |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622003681 |
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