Artificial axons as a biomimetic 3D myelination platform for the discovery and validation of promyelinating compounds

Abstract Multiple sclerosis (MS), a chronic neurodegenerative disease driven by damage to the protective myelin sheath, is currently incurable. Today, all clinically available treatments modulate the immune-mediated symptoms of the disease but they fail to stop neurodegeneration in many patients. Re...

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Bibliographic Details
Main Authors: Anna Jagielska, Kristin Radzwill, Daniela Espinosa-Hoyos, Mingyu Yang, Kavin Kowsari, Jonathan E. Farley, Stefanie Giera, Ann Byrne, Guoqing Sheng, Nicholas X. Fang, James C. Dodge, Carlos E. Pedraza, Krystyn J. Van Vliet
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-44675-6