ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication.

ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication.

Cellular antiviral programs encode molecules capable of targeting multiple steps in the virus lifecycle. Zinc-finger antiviral protein (ZAP) is a central and general regulator of antiviral activity that targets pathogen mRNA stability and translation. ZAP is diffusely cytoplasmic, but upon infection...

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Bibliographic Details
Main Authors: Lok Man John Law, Brandon S Razooky, Melody M H Li, Shihyun You, Andrea Jurado, Charles M Rice, Margaret R MacDonald
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007798

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