Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients
<p>Abstract</p> <p>Background</p> <p>Opportunistic oral infections can be found in over 80% of HIV + patients, often causing debilitating lesions that also contribute to deterioration in nutritional health. Although appreciation for the role that the microbiota is likel...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-07-01
|
| Series: | BMC Microbiology |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2180/12/153 |
| _version_ | 1818261005986168832 |
|---|---|
| author | Dang Angeline T Cotton Sean Sankaran-Walters Sumathi Li Chin-Shang Lee Chia-Yuan Dandekar Satya Paster Bruce J George Michael D |
| author_facet | Dang Angeline T Cotton Sean Sankaran-Walters Sumathi Li Chin-Shang Lee Chia-Yuan Dandekar Satya Paster Bruce J George Michael D |
| author_sort | Dang Angeline T |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Opportunistic oral infections can be found in over 80% of HIV + patients, often causing debilitating lesions that also contribute to deterioration in nutritional health. Although appreciation for the role that the microbiota is likely to play in the initiation and/or enhancement of oral infections has grown considerably in recent years, little is known about the impact of HIV infection on host-microbe interactions within the oral cavity. In the current study, we characterize modulations in the bacterial composition of the lingual microbiome in patients with treated and untreated HIV infection. Bacterial species profiles were elucidated by microarray assay and compared between untreated HIV infected patients, HIV infected patients receiving antiretroviral therapy, and healthy HIV negative controls. The relationship between clinical parameters (viral burden and CD4+ T cell depletion) and the loss or gain of bacterial species was evaluated in each HIV patient group.</p> <p>Results</p> <p>In untreated HIV infection, elevated viremia was associated with significantly higher proportions of potentially pathogenic <it>Veillonella</it>, <it>Prevotella</it>, <it>Megasphaera</it>, and <it>Campylobacter</it> species in the lingual microbiome than observed in healthy controls. The upsurge in the prevalence of potential pathogens was juxtaposed by diminished representation of commensal <it>Streptococcus</it> and <it>Veillonella</it> species. Colonization of <it>Neisseria flavescens</it> was lower in the lingual microbiome of HIV infected patients receiving antiretroviral therapy than in uninfected controls.</p> <p>Conclusions</p> <p>Our findings provide novel insights into the potential impact of HIV infection and antiretroviral therapy on the community structure of the oral microbiome, and implicate potential mechanisms that may increase the capacity of non-commensal species to gain a stronger foothold.</p> |
| first_indexed | 2024-12-12T18:40:21Z |
| format | Article |
| id | doaj.art-855a9962027c40b5bc61d03aeea432b6 |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-12-12T18:40:21Z |
| publishDate | 2012-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-855a9962027c40b5bc61d03aeea432b62022-12-22T00:15:39ZengBMCBMC Microbiology1471-21802012-07-0112115310.1186/1471-2180-12-153Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patientsDang Angeline TCotton SeanSankaran-Walters SumathiLi Chin-ShangLee Chia-YuanDandekar SatyaPaster Bruce JGeorge Michael D<p>Abstract</p> <p>Background</p> <p>Opportunistic oral infections can be found in over 80% of HIV + patients, often causing debilitating lesions that also contribute to deterioration in nutritional health. Although appreciation for the role that the microbiota is likely to play in the initiation and/or enhancement of oral infections has grown considerably in recent years, little is known about the impact of HIV infection on host-microbe interactions within the oral cavity. In the current study, we characterize modulations in the bacterial composition of the lingual microbiome in patients with treated and untreated HIV infection. Bacterial species profiles were elucidated by microarray assay and compared between untreated HIV infected patients, HIV infected patients receiving antiretroviral therapy, and healthy HIV negative controls. The relationship between clinical parameters (viral burden and CD4+ T cell depletion) and the loss or gain of bacterial species was evaluated in each HIV patient group.</p> <p>Results</p> <p>In untreated HIV infection, elevated viremia was associated with significantly higher proportions of potentially pathogenic <it>Veillonella</it>, <it>Prevotella</it>, <it>Megasphaera</it>, and <it>Campylobacter</it> species in the lingual microbiome than observed in healthy controls. The upsurge in the prevalence of potential pathogens was juxtaposed by diminished representation of commensal <it>Streptococcus</it> and <it>Veillonella</it> species. Colonization of <it>Neisseria flavescens</it> was lower in the lingual microbiome of HIV infected patients receiving antiretroviral therapy than in uninfected controls.</p> <p>Conclusions</p> <p>Our findings provide novel insights into the potential impact of HIV infection and antiretroviral therapy on the community structure of the oral microbiome, and implicate potential mechanisms that may increase the capacity of non-commensal species to gain a stronger foothold.</p>http://www.biomedcentral.com/1471-2180/12/153HIVMicrobiotaOral mucosaDysbiosisCD4+ T cellsStreptococcusCommensalMicrobiomeHOMIM |
| spellingShingle | Dang Angeline T Cotton Sean Sankaran-Walters Sumathi Li Chin-Shang Lee Chia-Yuan Dandekar Satya Paster Bruce J George Michael D Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients BMC Microbiology HIV Microbiota Oral mucosa Dysbiosis CD4+ T cells Streptococcus Commensal Microbiome HOMIM |
| title | Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients |
| title_full | Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients |
| title_fullStr | Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients |
| title_full_unstemmed | Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients |
| title_short | Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients |
| title_sort | evidence of an increased pathogenic footprint in the lingual microbiome of untreated hiv infected patients |
| topic | HIV Microbiota Oral mucosa Dysbiosis CD4+ T cells Streptococcus Commensal Microbiome HOMIM |
| url | http://www.biomedcentral.com/1471-2180/12/153 |
| work_keys_str_mv | AT dangangelinet evidenceofanincreasedpathogenicfootprintinthelingualmicrobiomeofuntreatedhivinfectedpatients AT cottonsean evidenceofanincreasedpathogenicfootprintinthelingualmicrobiomeofuntreatedhivinfectedpatients AT sankaranwalterssumathi evidenceofanincreasedpathogenicfootprintinthelingualmicrobiomeofuntreatedhivinfectedpatients AT lichinshang evidenceofanincreasedpathogenicfootprintinthelingualmicrobiomeofuntreatedhivinfectedpatients AT leechiayuan evidenceofanincreasedpathogenicfootprintinthelingualmicrobiomeofuntreatedhivinfectedpatients AT dandekarsatya evidenceofanincreasedpathogenicfootprintinthelingualmicrobiomeofuntreatedhivinfectedpatients AT pasterbrucej evidenceofanincreasedpathogenicfootprintinthelingualmicrobiomeofuntreatedhivinfectedpatients AT georgemichaeld evidenceofanincreasedpathogenicfootprintinthelingualmicrobiomeofuntreatedhivinfectedpatients |