High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis

High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis

Abstract Background Tryptophan 2,3-dioxygenase (TDO2) is the primary enzyme that catabolizes tryptophan to kynurenine. Numerous studies have suggested that TDO2 is involved in inflammation-related diseases. However, its role in osteoarthritis (OA) has not yet been investigated. The aim of the presen...

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Bibliographic Details
Main Authors: Genxiang Rong, Tao Zhang, Yayun Xu, Zhenyu Zhang, Binjie Gui, Kongzu Hu, Jinling Zhang, Zhi Tang, Cailiang Shen
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Musculoskeletal Disorders
Subjects:
Osteoarthritis
Tryptophan 2,3-dioxygenase
Synovial fluid
Synovium
Pro-inflammatory cytokines
Online Access:https://doi.org/10.1186/s12891-022-05567-4

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