Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant
Drug addiction: Dual-use vaccine shows promise for heroin and HIV A vaccine designed to treat heroin addiction while at the same time preventing HIV infection elicited strong immune responses in mice. Scientists from the US government led by Carl Alving from the Walter Reed Army Institute of Researc...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-05-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-017-0013-9 |
| _version_ | 1797641555017728000 |
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| author | Oscar B. Torres Gary R. Matyas Mangala Rao Kristina K. Peachman Rashmi Jalah Zoltan Beck Nelson L. Michael Kenner C. Rice Arthur E. Jacobson Carl R. Alving |
| author_facet | Oscar B. Torres Gary R. Matyas Mangala Rao Kristina K. Peachman Rashmi Jalah Zoltan Beck Nelson L. Michael Kenner C. Rice Arthur E. Jacobson Carl R. Alving |
| author_sort | Oscar B. Torres |
| collection | DOAJ |
| description | Drug addiction: Dual-use vaccine shows promise for heroin and HIV A vaccine designed to treat heroin addiction while at the same time preventing HIV infection elicited strong immune responses in mice. Scientists from the US government led by Carl Alving from the Walter Reed Army Institute of Research in Bethesda, Maryland, created a dual vaccine formulated with three main components: a segment of a protein expressed on the surface of HIV; synthetic molecules that resemble heroin and its degradation products; and a potent adjuvant to stimulate the immune system. Mice immunized with this vaccine had high antibody titers against the HIV surface protein as well as heroin and its derivatives. These mice also showed dulled responses to injected heroin. The findings suggest this vaccine strategy could help fight heroin abuse and the high risk of HIV infection among intravenous drug users. |
| first_indexed | 2024-03-11T13:47:20Z |
| format | Article |
| id | doaj.art-85620eb333114e65ac36983c03f03f2e |
| institution | Directory Open Access Journal |
| issn | 2059-0105 |
| language | English |
| last_indexed | 2024-03-11T13:47:20Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj.art-85620eb333114e65ac36983c03f03f2e2023-11-02T10:05:11ZengNature Portfolionpj Vaccines2059-01052017-05-01211810.1038/s41541-017-0013-9Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvantOscar B. Torres0Gary R. Matyas1Mangala Rao2Kristina K. Peachman3Rashmi Jalah4Zoltan Beck5Nelson L. Michael6Kenner C. Rice7Arthur E. Jacobson8Carl R. Alving9US Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military MedicineU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchUS Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military MedicineUS Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military MedicineUS Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military MedicineU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, National Institutes of HealthDepartment of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, National Institutes of HealthU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchDrug addiction: Dual-use vaccine shows promise for heroin and HIV A vaccine designed to treat heroin addiction while at the same time preventing HIV infection elicited strong immune responses in mice. Scientists from the US government led by Carl Alving from the Walter Reed Army Institute of Research in Bethesda, Maryland, created a dual vaccine formulated with three main components: a segment of a protein expressed on the surface of HIV; synthetic molecules that resemble heroin and its degradation products; and a potent adjuvant to stimulate the immune system. Mice immunized with this vaccine had high antibody titers against the HIV surface protein as well as heroin and its derivatives. These mice also showed dulled responses to injected heroin. The findings suggest this vaccine strategy could help fight heroin abuse and the high risk of HIV infection among intravenous drug users.https://doi.org/10.1038/s41541-017-0013-9 |
| spellingShingle | Oscar B. Torres Gary R. Matyas Mangala Rao Kristina K. Peachman Rashmi Jalah Zoltan Beck Nelson L. Michael Kenner C. Rice Arthur E. Jacobson Carl R. Alving Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant npj Vaccines |
| title | Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant |
| title_full | Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant |
| title_fullStr | Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant |
| title_full_unstemmed | Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant |
| title_short | Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant |
| title_sort | heroin hiv 1 h2 vaccine induction of dual immunologic effects with a heroin hapten conjugate and an hiv 1 envelope v2 peptide with liposomal lipid a as an adjuvant |
| url | https://doi.org/10.1038/s41541-017-0013-9 |
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