Silver and Antibiotic, New Facts to an Old Story
The therapeutic arsenal against bacterial infections is rapidly shrinking, as drug resistance spreads and pharmaceutical industry are struggling to produce new antibiotics. In this review we cover the efficacy of silver as an antibacterial agent. In particular we recall experimental evidences pointi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-08-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-6382/7/3/79 |
| _version_ | 1819090038989783040 |
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| author | Frédéric Barras Laurent Aussel Benjamin Ezraty |
| author_facet | Frédéric Barras Laurent Aussel Benjamin Ezraty |
| author_sort | Frédéric Barras |
| collection | DOAJ |
| description | The therapeutic arsenal against bacterial infections is rapidly shrinking, as drug resistance spreads and pharmaceutical industry are struggling to produce new antibiotics. In this review we cover the efficacy of silver as an antibacterial agent. In particular we recall experimental evidences pointing to the multiple targets of silver, including DNA, proteins and small molecules, and we review the arguments for and against the hypothesis that silver acts by enhancing oxidative stress. We also review the recent use of silver as an adjuvant for antibiotics. Specifically, we discuss the state of our current understanding on the potentiating action of silver ions on aminoglycoside antibiotics. |
| first_indexed | 2024-12-21T22:17:29Z |
| format | Article |
| id | doaj.art-8562bf47d4764f8182b30f98d7e459e9 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-21T22:17:29Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-8562bf47d4764f8182b30f98d7e459e92022-12-21T18:48:25ZengMDPI AGAntibiotics2079-63822018-08-01737910.3390/antibiotics7030079antibiotics7030079Silver and Antibiotic, New Facts to an Old StoryFrédéric Barras0Laurent Aussel1Benjamin Ezraty2Laboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), 13009 Marseille, FranceLaboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), 13009 Marseille, FranceLaboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), 13009 Marseille, FranceThe therapeutic arsenal against bacterial infections is rapidly shrinking, as drug resistance spreads and pharmaceutical industry are struggling to produce new antibiotics. In this review we cover the efficacy of silver as an antibacterial agent. In particular we recall experimental evidences pointing to the multiple targets of silver, including DNA, proteins and small molecules, and we review the arguments for and against the hypothesis that silver acts by enhancing oxidative stress. We also review the recent use of silver as an adjuvant for antibiotics. Specifically, we discuss the state of our current understanding on the potentiating action of silver ions on aminoglycoside antibiotics.http://www.mdpi.com/2079-6382/7/3/79silverantibioticsadjuvantcombinatorialmetalROS |
| spellingShingle | Frédéric Barras Laurent Aussel Benjamin Ezraty Silver and Antibiotic, New Facts to an Old Story Antibiotics silver antibiotics adjuvant combinatorial metal ROS |
| title | Silver and Antibiotic, New Facts to an Old Story |
| title_full | Silver and Antibiotic, New Facts to an Old Story |
| title_fullStr | Silver and Antibiotic, New Facts to an Old Story |
| title_full_unstemmed | Silver and Antibiotic, New Facts to an Old Story |
| title_short | Silver and Antibiotic, New Facts to an Old Story |
| title_sort | silver and antibiotic new facts to an old story |
| topic | silver antibiotics adjuvant combinatorial metal ROS |
| url | http://www.mdpi.com/2079-6382/7/3/79 |
| work_keys_str_mv | AT fredericbarras silverandantibioticnewfactstoanoldstory AT laurentaussel silverandantibioticnewfactstoanoldstory AT benjaminezraty silverandantibioticnewfactstoanoldstory |