Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymoma
Distinguishing T-lymphoblastic leukemia/lymphoma (T-ALL/T-LBL) from thymomas (especially B1 or B2 type) can be challenging particularly in limited trucut biopsy material where appreciating architecture is difficult or the background epithelial component does not provide tangible evidence for definit...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2024;volume=67;issue=1;spage=141;epage=144;aulast=Bansal |
| _version_ | 1797210110079008768 |
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| author | Divya Bansal Sunil Pasricha Gurudutt Gupta Anila Sharma Garima Durga Meenakshi Kamboj Anurag Mehta |
| author_facet | Divya Bansal Sunil Pasricha Gurudutt Gupta Anila Sharma Garima Durga Meenakshi Kamboj Anurag Mehta |
| author_sort | Divya Bansal |
| collection | DOAJ |
| description | Distinguishing T-lymphoblastic leukemia/lymphoma (T-ALL/T-LBL) from thymomas (especially B1 or B2 type) can be challenging particularly in limited trucut biopsy material where appreciating architecture is difficult or the background epithelial component does not provide tangible evidence for definite diagnosis. As a pathologist, it is important to accurately diagnose these neoplasms because they have entirely distinct management protocols. Recent studies have reported that LIM Domain Only 2 (LMO2) is expressed in neoplastic lymphoblasts of T-ALL/T-LBL and is absent in thymocytes of normal thymuses or thymomas. An observational study was done to test the sensitivity and specificity of LMO2 in differentiating neoplastic lymphoblasts from thymocytes of thymomas/normal thymuses. Our study showed that LMO2 had sensitivity of 70% and specificity of 100% in diagnosing LBL. None of the thymomas (B1 or B2 type) showed expression of LMO2 in the neoplastic cells. LMO2 is a reliable marker of transformed T-cell precursors and should be routinely included in immunohistochemical panel when evaluating thymic/mediastinal neoplasms. |
| first_indexed | 2024-04-24T10:05:23Z |
| format | Article |
| id | doaj.art-8563366482104f869b836d033af55516 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 0974-5130 |
| language | English |
| last_indexed | 2024-04-24T10:05:23Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-8563366482104f869b836d033af555162024-04-13T03:00:14ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-01-0167114114410.4103/ijpm.ijpm_111_23Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymomaDivya BansalSunil PasrichaGurudutt GuptaAnila SharmaGarima DurgaMeenakshi KambojAnurag MehtaDistinguishing T-lymphoblastic leukemia/lymphoma (T-ALL/T-LBL) from thymomas (especially B1 or B2 type) can be challenging particularly in limited trucut biopsy material where appreciating architecture is difficult or the background epithelial component does not provide tangible evidence for definite diagnosis. As a pathologist, it is important to accurately diagnose these neoplasms because they have entirely distinct management protocols. Recent studies have reported that LIM Domain Only 2 (LMO2) is expressed in neoplastic lymphoblasts of T-ALL/T-LBL and is absent in thymocytes of normal thymuses or thymomas. An observational study was done to test the sensitivity and specificity of LMO2 in differentiating neoplastic lymphoblasts from thymocytes of thymomas/normal thymuses. Our study showed that LMO2 had sensitivity of 70% and specificity of 100% in diagnosing LBL. None of the thymomas (B1 or B2 type) showed expression of LMO2 in the neoplastic cells. LMO2 is a reliable marker of transformed T-cell precursors and should be routinely included in immunohistochemical panel when evaluating thymic/mediastinal neoplasms.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2024;volume=67;issue=1;spage=141;epage=144;aulast=Bansalimmunohistochemistrylmo2mediastinumt-allthymomasthymust-lbl |
| spellingShingle | Divya Bansal Sunil Pasricha Gurudutt Gupta Anila Sharma Garima Durga Meenakshi Kamboj Anurag Mehta Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymoma Indian Journal of Pathology and Microbiology immunohistochemistry lmo2 mediastinum t-all thymomas thymus t-lbl |
| title | Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymoma |
| title_full | Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymoma |
| title_fullStr | Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymoma |
| title_full_unstemmed | Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymoma |
| title_short | Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymoma |
| title_sort | diagnostic utility of lmo2 immunohistochemistry in distinguishing t lymphoblastic leukemia lymphoma from thymoma |
| topic | immunohistochemistry lmo2 mediastinum t-all thymomas thymus t-lbl |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2024;volume=67;issue=1;spage=141;epage=144;aulast=Bansal |
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