Polysaccharides and Their Derivatives as Potential Antiviral Molecules
In the current context of the COVID-19 pandemic, it appears that our scientific resources and the medical community are not sufficiently developed to combat rapid viral spread all over the world. A number of viruses causing epidemics have already disseminated across the world in the last few years,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/2/426 |
| _version_ | 1797475925894365184 |
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| author | Hadrien Claus-Desbonnet Elsa Nikly Vanya Nalbantova Diana Karcheva-Bahchevanska Stanislava Ivanova Guillaume Pierre Niko Benbassat Plamen Katsarov Philippe Michaud Paolina Lukova Cédric Delattre |
| author_facet | Hadrien Claus-Desbonnet Elsa Nikly Vanya Nalbantova Diana Karcheva-Bahchevanska Stanislava Ivanova Guillaume Pierre Niko Benbassat Plamen Katsarov Philippe Michaud Paolina Lukova Cédric Delattre |
| author_sort | Hadrien Claus-Desbonnet |
| collection | DOAJ |
| description | In the current context of the COVID-19 pandemic, it appears that our scientific resources and the medical community are not sufficiently developed to combat rapid viral spread all over the world. A number of viruses causing epidemics have already disseminated across the world in the last few years, such as the dengue or chinkungunya virus, the Ebola virus, and other coronavirus families such as Middle East respiratory syndrome (MERS-CoV) and severe acute respiratory syndrome (SARS-CoV). The outbreaks of these infectious diseases have demonstrated the difficulty of treating an epidemic before the creation of vaccine. Different antiviral drugs already exist. However, several of them cause side effects or have lost their efficiency because of virus mutations. It is essential to develop new antiviral strategies, but ones that rely on more natural compounds to decrease the secondary effects. Polysaccharides, which have come to be known in recent years for their medicinal properties, including antiviral activities, are an excellent alternative. They are essential for the metabolism of plants, microorganisms, and animals, and are directly extractible. Polysaccharides have attracted more and more attention due to their therapeutic properties, low toxicity, and availability, and seem to be attractive candidates as antiviral drugs of tomorrow. |
| first_indexed | 2024-03-09T20:51:42Z |
| format | Article |
| id | doaj.art-856526b6aa5e4d9bab0aa2df8388b273 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T20:51:42Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-856526b6aa5e4d9bab0aa2df8388b2732023-11-23T22:32:42ZengMDPI AGViruses1999-49152022-02-0114242610.3390/v14020426Polysaccharides and Their Derivatives as Potential Antiviral MoleculesHadrien Claus-Desbonnet0Elsa Nikly1Vanya Nalbantova2Diana Karcheva-Bahchevanska3Stanislava Ivanova4Guillaume Pierre5Niko Benbassat6Plamen Katsarov7Philippe Michaud8Paolina Lukova9Cédric Delattre10Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, F-63000 Clermont-Ferrand, FranceUniversité Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, F-63000 Clermont-Ferrand, FranceDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, BulgariaDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, BulgariaDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, BulgariaUniversité Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, F-63000 Clermont-Ferrand, FranceDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, BulgariaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, BulgariaUniversité Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, F-63000 Clermont-Ferrand, FranceDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, BulgariaUniversité Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, F-63000 Clermont-Ferrand, FranceIn the current context of the COVID-19 pandemic, it appears that our scientific resources and the medical community are not sufficiently developed to combat rapid viral spread all over the world. A number of viruses causing epidemics have already disseminated across the world in the last few years, such as the dengue or chinkungunya virus, the Ebola virus, and other coronavirus families such as Middle East respiratory syndrome (MERS-CoV) and severe acute respiratory syndrome (SARS-CoV). The outbreaks of these infectious diseases have demonstrated the difficulty of treating an epidemic before the creation of vaccine. Different antiviral drugs already exist. However, several of them cause side effects or have lost their efficiency because of virus mutations. It is essential to develop new antiviral strategies, but ones that rely on more natural compounds to decrease the secondary effects. Polysaccharides, which have come to be known in recent years for their medicinal properties, including antiviral activities, are an excellent alternative. They are essential for the metabolism of plants, microorganisms, and animals, and are directly extractible. Polysaccharides have attracted more and more attention due to their therapeutic properties, low toxicity, and availability, and seem to be attractive candidates as antiviral drugs of tomorrow.https://www.mdpi.com/1999-4915/14/2/426polysaccharidesantiviral activitiesvirus and coronavirussevere acute respiratory syndromeSARS-CoVreplication inhibition |
| spellingShingle | Hadrien Claus-Desbonnet Elsa Nikly Vanya Nalbantova Diana Karcheva-Bahchevanska Stanislava Ivanova Guillaume Pierre Niko Benbassat Plamen Katsarov Philippe Michaud Paolina Lukova Cédric Delattre Polysaccharides and Their Derivatives as Potential Antiviral Molecules Viruses polysaccharides antiviral activities virus and coronavirus severe acute respiratory syndrome SARS-CoV replication inhibition |
| title | Polysaccharides and Their Derivatives as Potential Antiviral Molecules |
| title_full | Polysaccharides and Their Derivatives as Potential Antiviral Molecules |
| title_fullStr | Polysaccharides and Their Derivatives as Potential Antiviral Molecules |
| title_full_unstemmed | Polysaccharides and Their Derivatives as Potential Antiviral Molecules |
| title_short | Polysaccharides and Their Derivatives as Potential Antiviral Molecules |
| title_sort | polysaccharides and their derivatives as potential antiviral molecules |
| topic | polysaccharides antiviral activities virus and coronavirus severe acute respiratory syndrome SARS-CoV replication inhibition |
| url | https://www.mdpi.com/1999-4915/14/2/426 |
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