Clinical and Immunological Aspects of Pneumococcal Vaccination in Patients with Multiple Myeloma
Relevance. Among the groups at high risk of developing invasive pneumococcal infections, patients with multiple myeloma (MM) stand out among the highest rates of morbidity and mortality due to the presence of profound immunosuppression. Aims: to outline the current state of the problem of vaccine pr...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2021-01-01
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| Series: | Эпидемиология и вакцинопрофилактика |
| Subjects: | |
| Online Access: | https://www.epidemvac.ru/jour/article/view/1123 |
| _version_ | 1797879525409816576 |
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| author | I. O. Stoma |
| author_facet | I. O. Stoma |
| author_sort | I. O. Stoma |
| collection | DOAJ |
| description | Relevance. Among the groups at high risk of developing invasive pneumococcal infections, patients with multiple myeloma (MM) stand out among the highest rates of morbidity and mortality due to the presence of profound immunosuppression. Aims: to outline the current state of the problem of vaccine prevention of pneumococcal infection in patients receiving treatment for multiple myeloma, to present the evidence base for vaccination with conjugated pneumococcal vaccine. A continuous data review method was used to evaluate the studies on vaccination approaches against pneumococcal infection in patients with multiple myeloma. Conclusions. The article presents modern epidemiological data, as well as the results of original studies of clinical and immunological aspects of pneumococcal vaccination in patients with MM receiving new targeted agents and immunotherapy. The effectiveness of the use of the conjugated pneumococcal vaccine in patients treated with MM with bortezomib, lenalidomide, and ixazomib was indicated. An independent protective effect of pneumococcal vaccination has been shown as a preventive measure in a cohort of patients with MM, against the background of treatment with new targeted drugs. |
| first_indexed | 2024-04-10T02:50:02Z |
| format | Article |
| id | doaj.art-8567243a956f4fc488feb1af92a189f2 |
| institution | Directory Open Access Journal |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| last_indexed | 2024-04-10T02:50:02Z |
| publishDate | 2021-01-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj.art-8567243a956f4fc488feb1af92a189f22023-03-13T07:43:18ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942021-01-01196798510.31631/2073-3046-2020-19-6-79-85697Clinical and Immunological Aspects of Pneumococcal Vaccination in Patients with Multiple MyelomaI. O. Stoma0Гомельский государственный медицинский университетRelevance. Among the groups at high risk of developing invasive pneumococcal infections, patients with multiple myeloma (MM) stand out among the highest rates of morbidity and mortality due to the presence of profound immunosuppression. Aims: to outline the current state of the problem of vaccine prevention of pneumococcal infection in patients receiving treatment for multiple myeloma, to present the evidence base for vaccination with conjugated pneumococcal vaccine. A continuous data review method was used to evaluate the studies on vaccination approaches against pneumococcal infection in patients with multiple myeloma. Conclusions. The article presents modern epidemiological data, as well as the results of original studies of clinical and immunological aspects of pneumococcal vaccination in patients with MM receiving new targeted agents and immunotherapy. The effectiveness of the use of the conjugated pneumococcal vaccine in patients treated with MM with bortezomib, lenalidomide, and ixazomib was indicated. An independent protective effect of pneumococcal vaccination has been shown as a preventive measure in a cohort of patients with MM, against the background of treatment with new targeted drugs.https://www.epidemvac.ru/jour/article/view/1123пневмококковая инфекциявакцинациямножественная миеломапневмониятрансплантация |
| spellingShingle | I. O. Stoma Clinical and Immunological Aspects of Pneumococcal Vaccination in Patients with Multiple Myeloma Эпидемиология и вакцинопрофилактика пневмококковая инфекция вакцинация множественная миелома пневмония трансплантация |
| title | Clinical and Immunological Aspects of Pneumococcal Vaccination in Patients with Multiple Myeloma |
| title_full | Clinical and Immunological Aspects of Pneumococcal Vaccination in Patients with Multiple Myeloma |
| title_fullStr | Clinical and Immunological Aspects of Pneumococcal Vaccination in Patients with Multiple Myeloma |
| title_full_unstemmed | Clinical and Immunological Aspects of Pneumococcal Vaccination in Patients with Multiple Myeloma |
| title_short | Clinical and Immunological Aspects of Pneumococcal Vaccination in Patients with Multiple Myeloma |
| title_sort | clinical and immunological aspects of pneumococcal vaccination in patients with multiple myeloma |
| topic | пневмококковая инфекция вакцинация множественная миелома пневмония трансплантация |
| url | https://www.epidemvac.ru/jour/article/view/1123 |
| work_keys_str_mv | AT iostoma clinicalandimmunologicalaspectsofpneumococcalvaccinationinpatientswithmultiplemyeloma |