Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update
Neurotrophins are a family of proteins that regulate different aspects of biological development and neural function and are of great importance in neuroplasticity. This group of proteins has multiple functions in neuronal cells, as well as in other cellular populations. Nerve growth factor (NGF) is...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00939/full |
| _version_ | 1819065076868448256 |
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| author | Tinara Leila de Souza Aarão Jorge Rodrigues de Sousa Aline Semblano Carreira Falcão Luiz Fábio Magno Falcão Juarez Antônio Simões Quaresma Juarez Antônio Simões Quaresma Juarez Antônio Simões Quaresma |
| author_facet | Tinara Leila de Souza Aarão Jorge Rodrigues de Sousa Aline Semblano Carreira Falcão Luiz Fábio Magno Falcão Juarez Antônio Simões Quaresma Juarez Antônio Simões Quaresma Juarez Antônio Simões Quaresma |
| author_sort | Tinara Leila de Souza Aarão |
| collection | DOAJ |
| description | Neurotrophins are a family of proteins that regulate different aspects of biological development and neural function and are of great importance in neuroplasticity. This group of proteins has multiple functions in neuronal cells, as well as in other cellular populations. Nerve growth factor (NGF) is a neurotrophin that is endogenously produced during development and maturation by multiple cell types, including neurons, Schwann cells, oligodendrocytes, lymphocytes, mast cells, macrophages, keratinocytes, and fibroblasts. These cells produce proNGF, which is transformed by proteolytic cleavage into the biologically active NGF in the endoplasmic reticulum. The present review describes the role of NGF in the pathogenesis of leprosy and its correlations with different clinical forms of the disease and with the phenomena of regeneration and neural injury observed during infection. We discuss the involvement of NGF in the induction of neural damage and the pathophysiology of pain associated with peripheral neuropathy in leprosy. We also discuss the roles of immune factors in the evolution of this pathological process. Finally, we highlight avenues of investigation for future research to broaden our understanding of the role of NGF in the pathogenesis of leprosy. Our analysis of the literature indicates that NGF plays an important role in the evolution and outcome of Mycobacterium leprae infection. The findings described here highlight an important area of investigation, as leprosy is one of the main causes of infection in the peripheral nervous system. |
| first_indexed | 2024-12-21T15:40:43Z |
| format | Article |
| id | doaj.art-856863e57b594d348b7846a6e81c6bd3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T15:40:43Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-856863e57b594d348b7846a6e81c6bd32022-12-21T18:58:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-05-01910.3389/fimmu.2018.00939318440Nerve Growth Factor and Pathogenesis of Leprosy: Review and UpdateTinara Leila de Souza Aarão0Jorge Rodrigues de Sousa1Aline Semblano Carreira Falcão2Luiz Fábio Magno Falcão3Juarez Antônio Simões Quaresma4Juarez Antônio Simões Quaresma5Juarez Antônio Simões Quaresma6Center of Health and Biological Sciences, State University of Para, Belem, BrazilTropical Medicine Center, Federal University of Para, Belem, BrazilEvandro Chagas Institute, Ministry of Health, Ananindeua, BrazilCenter of Health and Biological Sciences, State University of Para, Belem, BrazilCenter of Health and Biological Sciences, State University of Para, Belem, BrazilTropical Medicine Center, Federal University of Para, Belem, BrazilEvandro Chagas Institute, Ministry of Health, Ananindeua, BrazilNeurotrophins are a family of proteins that regulate different aspects of biological development and neural function and are of great importance in neuroplasticity. This group of proteins has multiple functions in neuronal cells, as well as in other cellular populations. Nerve growth factor (NGF) is a neurotrophin that is endogenously produced during development and maturation by multiple cell types, including neurons, Schwann cells, oligodendrocytes, lymphocytes, mast cells, macrophages, keratinocytes, and fibroblasts. These cells produce proNGF, which is transformed by proteolytic cleavage into the biologically active NGF in the endoplasmic reticulum. The present review describes the role of NGF in the pathogenesis of leprosy and its correlations with different clinical forms of the disease and with the phenomena of regeneration and neural injury observed during infection. We discuss the involvement of NGF in the induction of neural damage and the pathophysiology of pain associated with peripheral neuropathy in leprosy. We also discuss the roles of immune factors in the evolution of this pathological process. Finally, we highlight avenues of investigation for future research to broaden our understanding of the role of NGF in the pathogenesis of leprosy. Our analysis of the literature indicates that NGF plays an important role in the evolution and outcome of Mycobacterium leprae infection. The findings described here highlight an important area of investigation, as leprosy is one of the main causes of infection in the peripheral nervous system.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00939/fullnerve growth factorleprosyMycobacterium lepraepathogenesisimmunology |
| spellingShingle | Tinara Leila de Souza Aarão Jorge Rodrigues de Sousa Aline Semblano Carreira Falcão Luiz Fábio Magno Falcão Juarez Antônio Simões Quaresma Juarez Antônio Simões Quaresma Juarez Antônio Simões Quaresma Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update Frontiers in Immunology nerve growth factor leprosy Mycobacterium leprae pathogenesis immunology |
| title | Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update |
| title_full | Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update |
| title_fullStr | Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update |
| title_full_unstemmed | Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update |
| title_short | Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update |
| title_sort | nerve growth factor and pathogenesis of leprosy review and update |
| topic | nerve growth factor leprosy Mycobacterium leprae pathogenesis immunology |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00939/full |
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