MicroRNA of Epithelial to Mesenchymal Transition in Fuchs’ Endothelial Corneal Dystrophy
Aim: a review of miRNA expression connected to epithelial mesenchymal transition studies in Fuchs’ endothelial corneal dystrophy (FECD). Methods: literature search strategy—PubMed central database, using “miRNA” or “microRNA” and “epithelial mesenchymal transition” or “EMT” and “Fuchs’ endothelial c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/10/1711 |
| _version_ | 1797473145263751168 |
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| author | Spela Stunf Pukl |
| author_facet | Spela Stunf Pukl |
| author_sort | Spela Stunf Pukl |
| collection | DOAJ |
| description | Aim: a review of miRNA expression connected to epithelial mesenchymal transition studies in Fuchs’ endothelial corneal dystrophy (FECD). Methods: literature search strategy—PubMed central database, using “miRNA” or “microRNA” and “epithelial mesenchymal transition” or “EMT” and “Fuchs’ endothelial corneal dystrophy” or “FECD” as keywords. Experimental or clinical studies on humans published in English regarding miRNA profiles of epithelial mesenchymal transition in Fuchs’ endothelial corneal dystrophy published between 2009 and 2022 were included. Conclusion: The publications regarding the miRNA profiles of epithelial mesenchymal transition in Fuchs’ endothelial corneal dystrophy are scarce but provide some valuable information about the potential biomarkers differentiating aging changes from early disease stages characterized by epithelial mesenchymal transition. In the corneal tissue of FECD patients, miRNA-184 seed-region mutation as well as unidirectional downregulation of total miRNA expression led by the miRNA-29 were demonstrated. For early diagnostics the miRNA of epithelial mesenchymal transition in aqueous humor should be analyzed and used as biomarkers. |
| first_indexed | 2024-03-09T20:11:44Z |
| format | Article |
| id | doaj.art-8568ec740c5844ffa6b57f2246afd2bc |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T20:11:44Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-8568ec740c5844ffa6b57f2246afd2bc2023-11-24T00:14:46ZengMDPI AGGenes2073-44252022-09-011310171110.3390/genes13101711MicroRNA of Epithelial to Mesenchymal Transition in Fuchs’ Endothelial Corneal DystrophySpela Stunf Pukl0Medical Faculty, University of Ljubljana, 1000 Ljubljana, SloveniaAim: a review of miRNA expression connected to epithelial mesenchymal transition studies in Fuchs’ endothelial corneal dystrophy (FECD). Methods: literature search strategy—PubMed central database, using “miRNA” or “microRNA” and “epithelial mesenchymal transition” or “EMT” and “Fuchs’ endothelial corneal dystrophy” or “FECD” as keywords. Experimental or clinical studies on humans published in English regarding miRNA profiles of epithelial mesenchymal transition in Fuchs’ endothelial corneal dystrophy published between 2009 and 2022 were included. Conclusion: The publications regarding the miRNA profiles of epithelial mesenchymal transition in Fuchs’ endothelial corneal dystrophy are scarce but provide some valuable information about the potential biomarkers differentiating aging changes from early disease stages characterized by epithelial mesenchymal transition. In the corneal tissue of FECD patients, miRNA-184 seed-region mutation as well as unidirectional downregulation of total miRNA expression led by the miRNA-29 were demonstrated. For early diagnostics the miRNA of epithelial mesenchymal transition in aqueous humor should be analyzed and used as biomarkers.https://www.mdpi.com/2073-4425/13/10/1711epithelial mesenchymal transitionFuchs’ endothelial corneal dystrophyFECDmiRNAmicroRNA |
| spellingShingle | Spela Stunf Pukl MicroRNA of Epithelial to Mesenchymal Transition in Fuchs’ Endothelial Corneal Dystrophy Genes epithelial mesenchymal transition Fuchs’ endothelial corneal dystrophy FECD miRNA microRNA |
| title | MicroRNA of Epithelial to Mesenchymal Transition in Fuchs’ Endothelial Corneal Dystrophy |
| title_full | MicroRNA of Epithelial to Mesenchymal Transition in Fuchs’ Endothelial Corneal Dystrophy |
| title_fullStr | MicroRNA of Epithelial to Mesenchymal Transition in Fuchs’ Endothelial Corneal Dystrophy |
| title_full_unstemmed | MicroRNA of Epithelial to Mesenchymal Transition in Fuchs’ Endothelial Corneal Dystrophy |
| title_short | MicroRNA of Epithelial to Mesenchymal Transition in Fuchs’ Endothelial Corneal Dystrophy |
| title_sort | microrna of epithelial to mesenchymal transition in fuchs endothelial corneal dystrophy |
| topic | epithelial mesenchymal transition Fuchs’ endothelial corneal dystrophy FECD miRNA microRNA |
| url | https://www.mdpi.com/2073-4425/13/10/1711 |
| work_keys_str_mv | AT spelastunfpukl micrornaofepithelialtomesenchymaltransitioninfuchsendothelialcornealdystrophy |