Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders
Abstract Background Recently, a systematic review and meta-analysis demonstrated that overexpression of p53 immunoprotein was significantly associated with progression risk of oral potentially malignant disorders (OPMD). However, the results of investigations on TP53 genetic typing in OPMD were inco...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-023-03316-0 |
| _version_ | 1797451277349683200 |
|---|---|
| author | Huangkai Li Yu Liu Shanxin Zhou Qin Zhou Xi Yang |
| author_facet | Huangkai Li Yu Liu Shanxin Zhou Qin Zhou Xi Yang |
| author_sort | Huangkai Li |
| collection | DOAJ |
| description | Abstract Background Recently, a systematic review and meta-analysis demonstrated that overexpression of p53 immunoprotein was significantly associated with progression risk of oral potentially malignant disorders (OPMD). However, the results of investigations on TP53 genetic typing in OPMD were inconsistent and inconclusive. Methods A systematic evaluation was conducted to identify all eligible case–control studies on the association of TP53 codon 72 polymorphism with both onset and progression of OPMD. Results A total of 768 OPMD patients and 1173 healthy individuals were identified from 12 eligible case–control studies on TP53 codon 72 polymorphism OPMD onset. In overall and subgroup analyses, no significantly risk of OPMD onset was observed in the cases for genetic models including allele C vs. G, homozygote CC vs. GG, heterozygote GC vs. GG, dominant GC + CC vs. GG, and recessive CC vs. GG + GC (all P-value of association test > 0.05). Further, a total of 465 OPMD patients and 775 oral squamous cell carcinoma (OSCC) ones were identified from 8 eligible case–control studies on this polymorphism in OPMD progression to OSCC. The analyses revealed that there was also no significantly risk of OPMD progression in the cases for the genetic models (all P-value of association test > 0.05). Conclusion Our data of a pooled-analysis indicates that TP53 codon 72 polymorphism may not act as genetic factor for the risk of OPMD onset and progression. Combined with the conclusion by a systematic review and meta-analysis, we put forward a new opinion that TP53 genetic typing cloud not influence p53 protein expression in OPMD. |
| first_indexed | 2024-03-09T14:51:23Z |
| format | Article |
| id | doaj.art-856aaf79845f436db21dce722de3e21a |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-09T14:51:23Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-856aaf79845f436db21dce722de3e21a2023-11-26T14:25:27ZengBMCBMC Oral Health1472-68312023-09-012311710.1186/s12903-023-03316-0Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disordersHuangkai Li0Yu Liu1Shanxin Zhou2Qin Zhou3Xi Yang4School of Stomatology, Hainan Medical CollegeDepartment of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineCollege of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of StomatologyCollege of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of StomatologySchool of Stomatology, Hainan Medical CollegeAbstract Background Recently, a systematic review and meta-analysis demonstrated that overexpression of p53 immunoprotein was significantly associated with progression risk of oral potentially malignant disorders (OPMD). However, the results of investigations on TP53 genetic typing in OPMD were inconsistent and inconclusive. Methods A systematic evaluation was conducted to identify all eligible case–control studies on the association of TP53 codon 72 polymorphism with both onset and progression of OPMD. Results A total of 768 OPMD patients and 1173 healthy individuals were identified from 12 eligible case–control studies on TP53 codon 72 polymorphism OPMD onset. In overall and subgroup analyses, no significantly risk of OPMD onset was observed in the cases for genetic models including allele C vs. G, homozygote CC vs. GG, heterozygote GC vs. GG, dominant GC + CC vs. GG, and recessive CC vs. GG + GC (all P-value of association test > 0.05). Further, a total of 465 OPMD patients and 775 oral squamous cell carcinoma (OSCC) ones were identified from 8 eligible case–control studies on this polymorphism in OPMD progression to OSCC. The analyses revealed that there was also no significantly risk of OPMD progression in the cases for the genetic models (all P-value of association test > 0.05). Conclusion Our data of a pooled-analysis indicates that TP53 codon 72 polymorphism may not act as genetic factor for the risk of OPMD onset and progression. Combined with the conclusion by a systematic review and meta-analysis, we put forward a new opinion that TP53 genetic typing cloud not influence p53 protein expression in OPMD.https://doi.org/10.1186/s12903-023-03316-0Oral potentially malignant disordersOral cancerTP53Meta-analysisSingle-nucleotide polymorphisms |
| spellingShingle | Huangkai Li Yu Liu Shanxin Zhou Qin Zhou Xi Yang Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders BMC Oral Health Oral potentially malignant disorders Oral cancer TP53 Meta-analysis Single-nucleotide polymorphisms |
| title | Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
| title_full | Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
| title_fullStr | Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
| title_full_unstemmed | Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
| title_short | Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
| title_sort | systematic evaluation of tp53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
| topic | Oral potentially malignant disorders Oral cancer TP53 Meta-analysis Single-nucleotide polymorphisms |
| url | https://doi.org/10.1186/s12903-023-03316-0 |
| work_keys_str_mv | AT huangkaili systematicevaluationoftp53codon72polymorphismassociatedwithonsetandprogressionoforalpotentiallymalignantdisorders AT yuliu systematicevaluationoftp53codon72polymorphismassociatedwithonsetandprogressionoforalpotentiallymalignantdisorders AT shanxinzhou systematicevaluationoftp53codon72polymorphismassociatedwithonsetandprogressionoforalpotentiallymalignantdisorders AT qinzhou systematicevaluationoftp53codon72polymorphismassociatedwithonsetandprogressionoforalpotentiallymalignantdisorders AT xiyang systematicevaluationoftp53codon72polymorphismassociatedwithonsetandprogressionoforalpotentiallymalignantdisorders |