Diabetes, Prediabetes, and the Risk of a Composite Outcome of Long-term Sickness Absence and Pre-retirement Death Due to Physical Disorders
Background: Diabetes and prediabetes have been linked with morbidity or mortality from cardiovascular disease, cancer, or other physical disorders among working-age populations, but less is known about outcomes directly related to labor loss (eg, Tlong-term sickness absence [LTSA] or pre-retirement...
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2024-03-01
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| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/34/3/34_JE20220245/_pdf |
| _version_ | 1797277227195301888 |
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| author | Ami Fukunaga Yosuke Inoue Tohru Nakagawa Toru Honda Shuichiro Yamamoto Hiroko Okazaki Makoto Yamamoto Toshiaki Miyamoto Takeshi Kochi Masafumi Eguchi Naoki Gommori Kenya Yamamoto Ai Hori Maki Konishi Nobumi Katayama Isamu Kabe Seitaro Dohi Tetsuya Mizoue |
| author_facet | Ami Fukunaga Yosuke Inoue Tohru Nakagawa Toru Honda Shuichiro Yamamoto Hiroko Okazaki Makoto Yamamoto Toshiaki Miyamoto Takeshi Kochi Masafumi Eguchi Naoki Gommori Kenya Yamamoto Ai Hori Maki Konishi Nobumi Katayama Isamu Kabe Seitaro Dohi Tetsuya Mizoue |
| author_sort | Ami Fukunaga |
| collection | DOAJ |
| description | Background: Diabetes and prediabetes have been linked with morbidity or mortality from cardiovascular disease, cancer, or other physical disorders among working-age populations, but less is known about outcomes directly related to labor loss (eg, Tlong-term sickness absence [LTSA] or pre-retirement death due to physical disorders). This prospective study aimed to examine the association of diabetes and prediabetes with the risk of a composite outcome of LTSA and pre-retirement death due to physical disorders. The present study also examined the associations of severe outcomes (LTSA or death) due to specific physical disorders or injuries/external causes in relation to diabetes and prediabetes. Methods: Data were derived from the Japan Epidemiology Collaboration on Occupational Health study. A total of 60,519 workers from 12 companies were followed for 8 years. Diabetes and prediabetes were defined based on the American Diabetes Association criteria. A Cox proportional hazards regression model was used to examine the association between diabetes/prediabetes and severe outcomes due to physical disorders or injuries/external causes. Results: The adjusted hazard ratios of severe outcomes due to all physical disorders were 1.22 (95% confidence interval [CI], 1.02–1.45) and 2.32 (95% CI, 2.04–2.64) for prediabetes and diabetes, respectively. In cause-specific analyses, an increased risk was observed for severe outcomes due to cancers, cardiovascular diseases, diseases of the musculoskeletal system, and injuries/external causes in relation to either or both diabetes and prediabetes. Conclusion: Diabetes and prediabetes were associated with an increased risk of severe outcomes due to physical disorders or injuries/external causes among Japanese workers. |
| first_indexed | 2024-03-07T15:44:36Z |
| format | Article |
| id | doaj.art-856ad6528126498d964498a53af58527 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-03-07T15:44:36Z |
| publishDate | 2024-03-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-856ad6528126498d964498a53af585272024-03-05T04:43:51ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922024-03-0134310511110.2188/jea.JE20220245Diabetes, Prediabetes, and the Risk of a Composite Outcome of Long-term Sickness Absence and Pre-retirement Death Due to Physical DisordersAmi Fukunaga0Yosuke Inoue1Tohru Nakagawa2Toru Honda3Shuichiro Yamamoto4Hiroko Okazaki5Makoto Yamamoto6Toshiaki Miyamoto7Takeshi Kochi8Masafumi Eguchi9Naoki Gommori10Kenya Yamamoto11Ai Hori12Maki Konishi13Nobumi Katayama14Isamu Kabe15Seitaro Dohi16Tetsuya Mizoue17Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, JapanDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, JapanHitachi Health Care Center, Hitachi, Ltd., Ibaraki, JapanHitachi Health Care Center, Hitachi, Ltd., Ibaraki, JapanHitachi Health Care Center, Hitachi, Ltd., Ibaraki, JapanMitsui Chemicals, Inc., Tokyo, JapanYamaha Corporation, Shizuoka, JapanEast Nippon Works, Nippon Steel Corporation, Chiba, JapanFurukawa Electric Co., Ltd., Tokyo, JapanFurukawa Electric Co., Ltd., Tokyo, JapanEast Japan Works (Keihin), JFE Steel Corporation, Kanagawa, JapanDivision of Chemical Information, National Institute of Occupational Safety and Health, Kanagawa, JapanDepartment of Global Public Health, Faculty of Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, JapanDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, JapanKubota Corporation, Tokyo, JapanMitsui Chemicals, Inc., Tokyo, JapanDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, JapanBackground: Diabetes and prediabetes have been linked with morbidity or mortality from cardiovascular disease, cancer, or other physical disorders among working-age populations, but less is known about outcomes directly related to labor loss (eg, Tlong-term sickness absence [LTSA] or pre-retirement death due to physical disorders). This prospective study aimed to examine the association of diabetes and prediabetes with the risk of a composite outcome of LTSA and pre-retirement death due to physical disorders. The present study also examined the associations of severe outcomes (LTSA or death) due to specific physical disorders or injuries/external causes in relation to diabetes and prediabetes. Methods: Data were derived from the Japan Epidemiology Collaboration on Occupational Health study. A total of 60,519 workers from 12 companies were followed for 8 years. Diabetes and prediabetes were defined based on the American Diabetes Association criteria. A Cox proportional hazards regression model was used to examine the association between diabetes/prediabetes and severe outcomes due to physical disorders or injuries/external causes. Results: The adjusted hazard ratios of severe outcomes due to all physical disorders were 1.22 (95% confidence interval [CI], 1.02–1.45) and 2.32 (95% CI, 2.04–2.64) for prediabetes and diabetes, respectively. In cause-specific analyses, an increased risk was observed for severe outcomes due to cancers, cardiovascular diseases, diseases of the musculoskeletal system, and injuries/external causes in relation to either or both diabetes and prediabetes. Conclusion: Diabetes and prediabetes were associated with an increased risk of severe outcomes due to physical disorders or injuries/external causes among Japanese workers.https://www.jstage.jst.go.jp/article/jea/34/3/34_JE20220245/_pdfdiabetesprediabetesmortalitysickness absencelabor loss |
| spellingShingle | Ami Fukunaga Yosuke Inoue Tohru Nakagawa Toru Honda Shuichiro Yamamoto Hiroko Okazaki Makoto Yamamoto Toshiaki Miyamoto Takeshi Kochi Masafumi Eguchi Naoki Gommori Kenya Yamamoto Ai Hori Maki Konishi Nobumi Katayama Isamu Kabe Seitaro Dohi Tetsuya Mizoue Diabetes, Prediabetes, and the Risk of a Composite Outcome of Long-term Sickness Absence and Pre-retirement Death Due to Physical Disorders Journal of Epidemiology diabetes prediabetes mortality sickness absence labor loss |
| title | Diabetes, Prediabetes, and the Risk of a Composite Outcome of Long-term Sickness Absence and Pre-retirement Death Due to Physical Disorders |
| title_full | Diabetes, Prediabetes, and the Risk of a Composite Outcome of Long-term Sickness Absence and Pre-retirement Death Due to Physical Disorders |
| title_fullStr | Diabetes, Prediabetes, and the Risk of a Composite Outcome of Long-term Sickness Absence and Pre-retirement Death Due to Physical Disorders |
| title_full_unstemmed | Diabetes, Prediabetes, and the Risk of a Composite Outcome of Long-term Sickness Absence and Pre-retirement Death Due to Physical Disorders |
| title_short | Diabetes, Prediabetes, and the Risk of a Composite Outcome of Long-term Sickness Absence and Pre-retirement Death Due to Physical Disorders |
| title_sort | diabetes prediabetes and the risk of a composite outcome of long term sickness absence and pre retirement death due to physical disorders |
| topic | diabetes prediabetes mortality sickness absence labor loss |
| url | https://www.jstage.jst.go.jp/article/jea/34/3/34_JE20220245/_pdf |
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