Chrysin increased progesterone and LH levels, estrous phase duration and altered uterine histology without affecting aromatase expression in rat ovary
The effect of chrysin, a flavonoid found in Passiflora spp., honey and propolis on female sex hormones and on ovarian and uterine histology was studied. Treatment of Wistar rats with chrysin (100 mg/kg) for 28 days resulted in persistent or prolonged estrous phase. Histologically, no difference was...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622000342 |
| _version_ | 1819291661500416000 |
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| author | Manal A. Abbas Khalid M. Alqaisi Ahmad Disi Naghm A. Hameed |
| author_facet | Manal A. Abbas Khalid M. Alqaisi Ahmad Disi Naghm A. Hameed |
| author_sort | Manal A. Abbas |
| collection | DOAJ |
| description | The effect of chrysin, a flavonoid found in Passiflora spp., honey and propolis on female sex hormones and on ovarian and uterine histology was studied. Treatment of Wistar rats with chrysin (100 mg/kg) for 28 days resulted in persistent or prolonged estrous phase. Histologically, no difference was found between different groups in the percentage of atretic preantral and antral follicles. Uteri of chrysin-treated groups had slit-like lumens during the estrous stage compared to the control group that had fluid-filled wide lumens. The height of luminal epithelium was higher in chrysin-treated groups and had more apoptotic cells. Immunohistochemical studies showed that chrysin had no effect on aromatase expression in the ovary or progesterone and estrogen-receptor alpha expression in the uterus. LH and progesterone, but not estrogen and FSH, levels were higher in chrysin-treated group. In conclusion, chrysin increased LH and progesterone levels and produced histological alterations in the uterus. |
| first_indexed | 2024-12-24T03:42:11Z |
| format | Article |
| id | doaj.art-856fe09ca2f040d38e1f152b58379922 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T03:42:11Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-856fe09ca2f040d38e1f152b583799222022-12-21T17:16:52ZengElsevierJournal of Functional Foods1756-46462022-02-0189104964Chrysin increased progesterone and LH levels, estrous phase duration and altered uterine histology without affecting aromatase expression in rat ovaryManal A. Abbas0Khalid M. Alqaisi1Ahmad Disi2Naghm A. Hameed3Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan; Pharmacological and Diagnostic Research Center (PDRC), Al-Ahliyya Amman University, Amman 19328, Jordan; Corresponding author at: Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan; Pharmacological and Diagnostic Research Center (PDRC), Al-Ahliyya Amman University, Amman 19328, JordanFaculty of Science, The University of Jordan, 11942 Amman, JordanFaculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, JordanThe effect of chrysin, a flavonoid found in Passiflora spp., honey and propolis on female sex hormones and on ovarian and uterine histology was studied. Treatment of Wistar rats with chrysin (100 mg/kg) for 28 days resulted in persistent or prolonged estrous phase. Histologically, no difference was found between different groups in the percentage of atretic preantral and antral follicles. Uteri of chrysin-treated groups had slit-like lumens during the estrous stage compared to the control group that had fluid-filled wide lumens. The height of luminal epithelium was higher in chrysin-treated groups and had more apoptotic cells. Immunohistochemical studies showed that chrysin had no effect on aromatase expression in the ovary or progesterone and estrogen-receptor alpha expression in the uterus. LH and progesterone, but not estrogen and FSH, levels were higher in chrysin-treated group. In conclusion, chrysin increased LH and progesterone levels and produced histological alterations in the uterus.http://www.sciencedirect.com/science/article/pii/S1756464622000342ChrysinEstrousLHOvarian follicleProgesteroneUterus |
| spellingShingle | Manal A. Abbas Khalid M. Alqaisi Ahmad Disi Naghm A. Hameed Chrysin increased progesterone and LH levels, estrous phase duration and altered uterine histology without affecting aromatase expression in rat ovary Journal of Functional Foods Chrysin Estrous LH Ovarian follicle Progesterone Uterus |
| title | Chrysin increased progesterone and LH levels, estrous phase duration and altered uterine histology without affecting aromatase expression in rat ovary |
| title_full | Chrysin increased progesterone and LH levels, estrous phase duration and altered uterine histology without affecting aromatase expression in rat ovary |
| title_fullStr | Chrysin increased progesterone and LH levels, estrous phase duration and altered uterine histology without affecting aromatase expression in rat ovary |
| title_full_unstemmed | Chrysin increased progesterone and LH levels, estrous phase duration and altered uterine histology without affecting aromatase expression in rat ovary |
| title_short | Chrysin increased progesterone and LH levels, estrous phase duration and altered uterine histology without affecting aromatase expression in rat ovary |
| title_sort | chrysin increased progesterone and lh levels estrous phase duration and altered uterine histology without affecting aromatase expression in rat ovary |
| topic | Chrysin Estrous LH Ovarian follicle Progesterone Uterus |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622000342 |
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