Establishment of a Tissue-Mimicking Surrogate for Pulmonary Lesions to Improve the Development of RFA Instruments and Algorithms
(1) Development of radiofrequency ablation (RFA) systems for pulmonary lesions is restricted by availability of human tumor specimens and limited comparability of animal tissue. We aimed to develop a new surrogate tissue overcoming these drawbacks. (2) Reference values for electrical impedance in lu...
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/1100 |
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| author | Louisa Bühler Markus D. Enderle Nicolas Kahn Markus Polke Marc A. Schneider Claus Peter Heußel Felix J. F. Herth Walter Linzenbold |
| author_facet | Louisa Bühler Markus D. Enderle Nicolas Kahn Markus Polke Marc A. Schneider Claus Peter Heußel Felix J. F. Herth Walter Linzenbold |
| author_sort | Louisa Bühler |
| collection | DOAJ |
| description | (1) Development of radiofrequency ablation (RFA) systems for pulmonary lesions is restricted by availability of human tumor specimens and limited comparability of animal tissue. We aimed to develop a new surrogate tissue overcoming these drawbacks. (2) Reference values for electrical impedance in lung tumor tissue were collected during routine lung tumor RFA (<i>n</i> = 10). Subsequently, a tissue-mimicking surrogate with comparable electrical impedance and facilitating detection of the ablation margins was developed. (3) The mean electrical impedance for all patients was 103.5 ± 14.7 Ω. In the optimized surrogate tissue model consisting of 68% agar solution, 23% egg yolk, 9% thermochromic ink, and variable amounts of sodium chloride, the mean electrical impedance was adjustable from 74.3 ± 0.4 Ω to 183.2 ± 5.6 Ω and was a function (y = 368.4x + 175.2; R<sup>2</sup> = 0.96; <i>p</i> < 0.001) of sodium chloride concentration (between 0 and 0.3%). The surrogate tissue achieved sufficient dimensional stability, and sample cuts revealed clear margins of color change for temperatures higher 60 °C. (4) The tissue-mimicking surrogate can be adapted to lung tumor with respect to its electrical properties. As the surrogate tissue allows for simple and cost-effective manufacturing, it is suitable for extensive laboratory testing of RFA systems for pulmonary ablation. |
| first_indexed | 2024-03-10T03:17:35Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:17:35Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-85714c2446c04d2fbc2446b8b08480a42023-11-23T10:11:03ZengMDPI AGBiomedicines2227-90592022-05-01105110010.3390/biomedicines10051100Establishment of a Tissue-Mimicking Surrogate for Pulmonary Lesions to Improve the Development of RFA Instruments and AlgorithmsLouisa Bühler0Markus D. Enderle1Nicolas Kahn2Markus Polke3Marc A. Schneider4Claus Peter Heußel5Felix J. F. Herth6Walter Linzenbold7Erbe Elektromedizin GmbH, 72072 Tübingen, GermanyErbe Elektromedizin GmbH, 72072 Tübingen, GermanyDepartment of Pneumology and Respiratory Care Medicine, Thoraxklinik at Heidelberg University Hospital, 69126 Heidelberg, GermanyDepartment of Pneumology and Respiratory Care Medicine, Thoraxklinik at Heidelberg University Hospital, 69126 Heidelberg, GermanyTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), University of Heidelberg, 69120 Heidelberg, GermanyTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), University of Heidelberg, 69120 Heidelberg, GermanyDepartment of Pneumology and Respiratory Care Medicine, Thoraxklinik at Heidelberg University Hospital, 69126 Heidelberg, GermanyErbe Elektromedizin GmbH, 72072 Tübingen, Germany(1) Development of radiofrequency ablation (RFA) systems for pulmonary lesions is restricted by availability of human tumor specimens and limited comparability of animal tissue. We aimed to develop a new surrogate tissue overcoming these drawbacks. (2) Reference values for electrical impedance in lung tumor tissue were collected during routine lung tumor RFA (<i>n</i> = 10). Subsequently, a tissue-mimicking surrogate with comparable electrical impedance and facilitating detection of the ablation margins was developed. (3) The mean electrical impedance for all patients was 103.5 ± 14.7 Ω. In the optimized surrogate tissue model consisting of 68% agar solution, 23% egg yolk, 9% thermochromic ink, and variable amounts of sodium chloride, the mean electrical impedance was adjustable from 74.3 ± 0.4 Ω to 183.2 ± 5.6 Ω and was a function (y = 368.4x + 175.2; R<sup>2</sup> = 0.96; <i>p</i> < 0.001) of sodium chloride concentration (between 0 and 0.3%). The surrogate tissue achieved sufficient dimensional stability, and sample cuts revealed clear margins of color change for temperatures higher 60 °C. (4) The tissue-mimicking surrogate can be adapted to lung tumor with respect to its electrical properties. As the surrogate tissue allows for simple and cost-effective manufacturing, it is suitable for extensive laboratory testing of RFA systems for pulmonary ablation.https://www.mdpi.com/2227-9059/10/5/1100tissue-mimicking phantomthermochromicagarradiofrequency ablationelectrical impedancelung cancer |
| spellingShingle | Louisa Bühler Markus D. Enderle Nicolas Kahn Markus Polke Marc A. Schneider Claus Peter Heußel Felix J. F. Herth Walter Linzenbold Establishment of a Tissue-Mimicking Surrogate for Pulmonary Lesions to Improve the Development of RFA Instruments and Algorithms Biomedicines tissue-mimicking phantom thermochromic agar radiofrequency ablation electrical impedance lung cancer |
| title | Establishment of a Tissue-Mimicking Surrogate for Pulmonary Lesions to Improve the Development of RFA Instruments and Algorithms |
| title_full | Establishment of a Tissue-Mimicking Surrogate for Pulmonary Lesions to Improve the Development of RFA Instruments and Algorithms |
| title_fullStr | Establishment of a Tissue-Mimicking Surrogate for Pulmonary Lesions to Improve the Development of RFA Instruments and Algorithms |
| title_full_unstemmed | Establishment of a Tissue-Mimicking Surrogate for Pulmonary Lesions to Improve the Development of RFA Instruments and Algorithms |
| title_short | Establishment of a Tissue-Mimicking Surrogate for Pulmonary Lesions to Improve the Development of RFA Instruments and Algorithms |
| title_sort | establishment of a tissue mimicking surrogate for pulmonary lesions to improve the development of rfa instruments and algorithms |
| topic | tissue-mimicking phantom thermochromic agar radiofrequency ablation electrical impedance lung cancer |
| url | https://www.mdpi.com/2227-9059/10/5/1100 |
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