MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis.

MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis.

Endocrine resistance and metastatic progression are primary causes of treatment failure in breast cancer. While mitogen activated protein kinases (MAPKs) are known to promote ligand-independent cell growth, the role of the MEK5-ERK5 pathway in the progression of clinical breast carcinoma remains poo...

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Bibliographic Details
Main Authors: James W Antoon, Elizabeth C Martin, Rongye Lai, Virgilo A Salvo, Yan Tang, Ashley M Nitzchke, Steven Elliott, Seung Yoon Nam, Wei Xiong, Lyndsay V Rhodes, Bridgette Collins-Burow, Odile David, Guandi Wang, Bin Shan, Barbara S Beckman, Kenneth P Nephew, Matthew E Burow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3739787?pdf=render

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