A randomized, cross‐over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence

A randomized, cross‐over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence

Abstract There are limited comparison data throughout the dosing interval for generic versus brand metoprolol extended‐release (ER) tablets. We compared the pharmacokinetics (PKs) and pharmacodynamics of brand name versus two generic formulations (drugs 1 and 2) of metoprolol ER tablets with differe...

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Main Authors: Scott A. Mosley, Sarah Kim, Nihal El Rouby, Karthik Lingineni, Valvanera Vozmediano Esteban, Yan Gong, Yiqing Chen, David Estores, Kairui Feng, Hyewon Kim, Minori Kinjo, Taimour Langaee, Zhichuan Li, Siegfried O. F. Schmidt, Julie A. Johnson, Reginald F. Frye, Lanyan (Lucy) Fang, Liang Zhao, Philip F. Binkley, Stephan Schmidt, Larisa H. Cavallari
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13294

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