Cognitive function assessment during 2 mA transcranial direct current stimulation in DLPFC in healthy volunteers
Abstract Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-10-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.14264 |
| _version_ | 1818110710919462912 |
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| author | Shahid Bashir Fawaz Al‐Hussain Ali Hamza Talha Asim Niaz Raidah Albaradie Syed S. Habib |
| author_facet | Shahid Bashir Fawaz Al‐Hussain Ali Hamza Talha Asim Niaz Raidah Albaradie Syed S. Habib |
| author_sort | Shahid Bashir |
| collection | DOAJ |
| description | Abstract Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess the online effect of tDCS over the left dorsolateral prefrontal cortex (DLPFC) on cognitive function and obtain safety data in healthy adults. We recruited 36 healthy (20 male) participants for this double‐blind, sham‐controlled parallel design. We used Stop Signal Task (SST) Go Trial and Pattern Recognition Memory (PRM) tests to evaluate cognitive function during 2 mA (20 min) anodal or sham tDCS stimulation over the left DLPFC. In active conditions, left dorsolateral prefrontal cortex was selected for electrode placement with reference over right supraorbital cortex. All related tasks were done during the online tDCS section in both groups (active/sham). There were statistically significant differences in cognitive function according to the PRM test (P = 0.003), SST (P = 0.021), and SST correct response time on Go Trials (P = 0.02) during active stimulation compared to the sham group. Our results reveal that cognitive performance is affected by a single dose of active online tDCS over DLPFC area compared to sham stimulation. In our study, tDCS is well‐tolerated and safe that further supports the safety of tDCS in local healthy population. |
| first_indexed | 2024-12-11T02:51:29Z |
| format | Article |
| id | doaj.art-85727aa6141a4dd88ab89a3d326f6525 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-11T02:51:29Z |
| publishDate | 2019-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-85727aa6141a4dd88ab89a3d326f65252022-12-22T01:23:17ZengWileyPhysiological Reports2051-817X2019-10-01720n/an/a10.14814/phy2.14264Cognitive function assessment during 2 mA transcranial direct current stimulation in DLPFC in healthy volunteersShahid Bashir0Fawaz Al‐Hussain1Ali Hamza2Talha Asim Niaz3Raidah Albaradie4Syed S. Habib5Neuroscience CenterKing Fahad Specialist Hospital Dammam Dammam Saudi ArabiaDepartment of Neurology College of Medicine King Saud University Riyadh Saudi ArabiaDepartment of Electrical Engineering National University of Computer and Emerging Sciences Lahore PakistanNeuroscience CenterKing Fahad Specialist Hospital Dammam Dammam Saudi ArabiaNeuroscience CenterKing Fahad Specialist Hospital Dammam Dammam Saudi ArabiaDepartment of Physiology College of Medicine King Saud University Riyadh Saudi ArabiaAbstract Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess the online effect of tDCS over the left dorsolateral prefrontal cortex (DLPFC) on cognitive function and obtain safety data in healthy adults. We recruited 36 healthy (20 male) participants for this double‐blind, sham‐controlled parallel design. We used Stop Signal Task (SST) Go Trial and Pattern Recognition Memory (PRM) tests to evaluate cognitive function during 2 mA (20 min) anodal or sham tDCS stimulation over the left DLPFC. In active conditions, left dorsolateral prefrontal cortex was selected for electrode placement with reference over right supraorbital cortex. All related tasks were done during the online tDCS section in both groups (active/sham). There were statistically significant differences in cognitive function according to the PRM test (P = 0.003), SST (P = 0.021), and SST correct response time on Go Trials (P = 0.02) during active stimulation compared to the sham group. Our results reveal that cognitive performance is affected by a single dose of active online tDCS over DLPFC area compared to sham stimulation. In our study, tDCS is well‐tolerated and safe that further supports the safety of tDCS in local healthy population.https://doi.org/10.14814/phy2.14264Memorysafetystop signal tasktranscranial direct current stimulation |
| spellingShingle | Shahid Bashir Fawaz Al‐Hussain Ali Hamza Talha Asim Niaz Raidah Albaradie Syed S. Habib Cognitive function assessment during 2 mA transcranial direct current stimulation in DLPFC in healthy volunteers Physiological Reports Memory safety stop signal task transcranial direct current stimulation |
| title | Cognitive function assessment during 2 mA transcranial direct current stimulation in DLPFC in healthy volunteers |
| title_full | Cognitive function assessment during 2 mA transcranial direct current stimulation in DLPFC in healthy volunteers |
| title_fullStr | Cognitive function assessment during 2 mA transcranial direct current stimulation in DLPFC in healthy volunteers |
| title_full_unstemmed | Cognitive function assessment during 2 mA transcranial direct current stimulation in DLPFC in healthy volunteers |
| title_short | Cognitive function assessment during 2 mA transcranial direct current stimulation in DLPFC in healthy volunteers |
| title_sort | cognitive function assessment during 2 ma transcranial direct current stimulation in dlpfc in healthy volunteers |
| topic | Memory safety stop signal task transcranial direct current stimulation |
| url | https://doi.org/10.14814/phy2.14264 |
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