Plasmonic nanosensors for point-of-care biomarker detection
Advancement of materials along with their fascinating properties play increasingly important role in facilitating the rapid progress in medicine. An excellent example is the recent development of biosensors based on nanomaterials that induce surface plasmon effect for screening biomarkers of various...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422000618 |
| _version_ | 1828516569066504192 |
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| author | Congran Jin Ziqian Wu John H. Molinski Junhu Zhou Yundong Ren John X.J. Zhang |
| author_facet | Congran Jin Ziqian Wu John H. Molinski Junhu Zhou Yundong Ren John X.J. Zhang |
| author_sort | Congran Jin |
| collection | DOAJ |
| description | Advancement of materials along with their fascinating properties play increasingly important role in facilitating the rapid progress in medicine. An excellent example is the recent development of biosensors based on nanomaterials that induce surface plasmon effect for screening biomarkers of various diseases ranging from cancer to Covid-19. The recent global pandemic re-confirmed the trend of real-time diagnosis in public health to be in point-of-care (POC) settings that can screen interested biomarkers at home, or literally anywhere else, at any time. Plasmonic biosensors, thanks to its versatile designs and extraordinary sensitivities, can be scaled into small and portable devices for POC diagnostic tools. In the meantime, efforts are being made to speed up, simplify and lower the cost of the signal readout process including converting the conventional heavy laboratory instruments into lightweight handheld devices. This article reviews the recent progress on the design of plasmonic nanomaterial-based biosensors for biomarker detection with a perspective of POC applications. After briefly introducing the plasmonic detection working mechanisms and devices, the selected highlights in the field focusing on the technology's design including nanomaterials development, structure assembly, and target applications are presented and analyzed. In parallel, discussions on the sensor's current or potential applicability in POC diagnosis are provided. Finally, challenges and opportunities in plasmonic biosensor for biomarker detection, such as the current Covid-19 pandemic and its testing using plasmonic biosensor and incorporation of machine learning algorithms are discussed. |
| first_indexed | 2024-12-11T18:29:46Z |
| format | Article |
| id | doaj.art-8574f7b501544bf5b4220d6546b26092 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-12-11T18:29:46Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-8574f7b501544bf5b4220d6546b260922022-12-22T00:54:57ZengElsevierMaterials Today Bio2590-00642022-03-0114100263Plasmonic nanosensors for point-of-care biomarker detectionCongran Jin0Ziqian Wu1John H. Molinski2Junhu Zhou3Yundong Ren4John X.J. Zhang5Thayer School of Engineering, Dartmouth College, NH, USAThayer School of Engineering, Dartmouth College, NH, USAThayer School of Engineering, Dartmouth College, NH, USAThayer School of Engineering, Dartmouth College, NH, USAThayer School of Engineering, Dartmouth College, NH, USACorresponding author.; Thayer School of Engineering, Dartmouth College, NH, USAAdvancement of materials along with their fascinating properties play increasingly important role in facilitating the rapid progress in medicine. An excellent example is the recent development of biosensors based on nanomaterials that induce surface plasmon effect for screening biomarkers of various diseases ranging from cancer to Covid-19. The recent global pandemic re-confirmed the trend of real-time diagnosis in public health to be in point-of-care (POC) settings that can screen interested biomarkers at home, or literally anywhere else, at any time. Plasmonic biosensors, thanks to its versatile designs and extraordinary sensitivities, can be scaled into small and portable devices for POC diagnostic tools. In the meantime, efforts are being made to speed up, simplify and lower the cost of the signal readout process including converting the conventional heavy laboratory instruments into lightweight handheld devices. This article reviews the recent progress on the design of plasmonic nanomaterial-based biosensors for biomarker detection with a perspective of POC applications. After briefly introducing the plasmonic detection working mechanisms and devices, the selected highlights in the field focusing on the technology's design including nanomaterials development, structure assembly, and target applications are presented and analyzed. In parallel, discussions on the sensor's current or potential applicability in POC diagnosis are provided. Finally, challenges and opportunities in plasmonic biosensor for biomarker detection, such as the current Covid-19 pandemic and its testing using plasmonic biosensor and incorporation of machine learning algorithms are discussed.http://www.sciencedirect.com/science/article/pii/S2590006422000618PlasmonicBiosensorPoint-of-careBiomarkerCovid-19 |
| spellingShingle | Congran Jin Ziqian Wu John H. Molinski Junhu Zhou Yundong Ren John X.J. Zhang Plasmonic nanosensors for point-of-care biomarker detection Materials Today Bio Plasmonic Biosensor Point-of-care Biomarker Covid-19 |
| title | Plasmonic nanosensors for point-of-care biomarker detection |
| title_full | Plasmonic nanosensors for point-of-care biomarker detection |
| title_fullStr | Plasmonic nanosensors for point-of-care biomarker detection |
| title_full_unstemmed | Plasmonic nanosensors for point-of-care biomarker detection |
| title_short | Plasmonic nanosensors for point-of-care biomarker detection |
| title_sort | plasmonic nanosensors for point of care biomarker detection |
| topic | Plasmonic Biosensor Point-of-care Biomarker Covid-19 |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422000618 |
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