A serological survey of antibodies to H5, H7 and H9 avian influenza viruses amongst the duck-related workers in Beijing, China.
The continued spread of highly pathogenic avian influenza (HPAI) viruses of H5 and H7 subtypes and low pathogenic avian influenza (LPAI) viruses of H5, H7 and H9 subtypes in birds and the subsequent infections in humans pose an ongoing pandemic threat. It has been proposed that poultry workers are a...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3511333?pdf=render |
| _version_ | 1811264647181893632 |
|---|---|
| author | Peng Yang Chunna Ma Weixian Shi Shujuan Cui Guilan Lu Xiaomin Peng Daitao Zhang Yimeng Liu Huijie Liang Yi Zhang Li Zhang Holly Seale Quanyi Wang |
| author_facet | Peng Yang Chunna Ma Weixian Shi Shujuan Cui Guilan Lu Xiaomin Peng Daitao Zhang Yimeng Liu Huijie Liang Yi Zhang Li Zhang Holly Seale Quanyi Wang |
| author_sort | Peng Yang |
| collection | DOAJ |
| description | The continued spread of highly pathogenic avian influenza (HPAI) viruses of H5 and H7 subtypes and low pathogenic avian influenza (LPAI) viruses of H5, H7 and H9 subtypes in birds and the subsequent infections in humans pose an ongoing pandemic threat. It has been proposed that poultry workers are at higher risk of exposure to HPAI or LPAI viruses and subsequently infection due to their repeated exposure to chickens or domestic waterfowl. The aim of this study was to examine the seroprevalence of antibodies against H5, H7 and H9 viruses amongst duck-related workers in Beijing, China and the risk factors associated with seropositivity. In March, 2011, 1741 participants were recruited from (1) commercial duck-breeding farms; (2) private duck-breeding farms; and (3) duck-slaughtering farms. Local villagers who bred ducks in their backyards were also recruited. A survey was administered by face-to-face interview, and blood samples were collected from subjects for antibody testing against H5, H7 and H9 viruses. We found that none of the subjects were seropositive for either H5 or H7 viruses, and only 0.7% (12/1741) had antibody against H9. A statistically significant difference in H9 antibody seroprevalence existed between the various categories of workers (P = 0.005), with the highest figures recorded amongst the villagers (1.7%). Independent risk factors associated with seropositivity toinfection with H9 virus included less frequent disinfection of worksite (OR, 5.13 [95% CI, 1.07-24.58]; P = 0.041; ≤ twice monthly versus>twice monthly) and handling ducks with wounds on hands (OR, 4.13 [95% CI, 1.26-13.57]; P = 0.019). Whilst the risk of infection with H5, H7 and H9 viruses appears to be low among duck-related workers in Beijing, China, ongoing monitoring of infection with the H9 virus is still warranted, especially amongst villagers who breed backyard ducks to monitor for any changes. |
| first_indexed | 2024-04-12T20:08:11Z |
| format | Article |
| id | doaj.art-85762a13828d42a7bd04ea1f9ca28a94 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T20:08:11Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-85762a13828d42a7bd04ea1f9ca28a942022-12-22T03:18:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e5077010.1371/journal.pone.0050770A serological survey of antibodies to H5, H7 and H9 avian influenza viruses amongst the duck-related workers in Beijing, China.Peng YangChunna MaWeixian ShiShujuan CuiGuilan LuXiaomin PengDaitao ZhangYimeng LiuHuijie LiangYi ZhangLi ZhangHolly SealeQuanyi WangThe continued spread of highly pathogenic avian influenza (HPAI) viruses of H5 and H7 subtypes and low pathogenic avian influenza (LPAI) viruses of H5, H7 and H9 subtypes in birds and the subsequent infections in humans pose an ongoing pandemic threat. It has been proposed that poultry workers are at higher risk of exposure to HPAI or LPAI viruses and subsequently infection due to their repeated exposure to chickens or domestic waterfowl. The aim of this study was to examine the seroprevalence of antibodies against H5, H7 and H9 viruses amongst duck-related workers in Beijing, China and the risk factors associated with seropositivity. In March, 2011, 1741 participants were recruited from (1) commercial duck-breeding farms; (2) private duck-breeding farms; and (3) duck-slaughtering farms. Local villagers who bred ducks in their backyards were also recruited. A survey was administered by face-to-face interview, and blood samples were collected from subjects for antibody testing against H5, H7 and H9 viruses. We found that none of the subjects were seropositive for either H5 or H7 viruses, and only 0.7% (12/1741) had antibody against H9. A statistically significant difference in H9 antibody seroprevalence existed between the various categories of workers (P = 0.005), with the highest figures recorded amongst the villagers (1.7%). Independent risk factors associated with seropositivity toinfection with H9 virus included less frequent disinfection of worksite (OR, 5.13 [95% CI, 1.07-24.58]; P = 0.041; ≤ twice monthly versus>twice monthly) and handling ducks with wounds on hands (OR, 4.13 [95% CI, 1.26-13.57]; P = 0.019). Whilst the risk of infection with H5, H7 and H9 viruses appears to be low among duck-related workers in Beijing, China, ongoing monitoring of infection with the H9 virus is still warranted, especially amongst villagers who breed backyard ducks to monitor for any changes.http://europepmc.org/articles/PMC3511333?pdf=render |
| spellingShingle | Peng Yang Chunna Ma Weixian Shi Shujuan Cui Guilan Lu Xiaomin Peng Daitao Zhang Yimeng Liu Huijie Liang Yi Zhang Li Zhang Holly Seale Quanyi Wang A serological survey of antibodies to H5, H7 and H9 avian influenza viruses amongst the duck-related workers in Beijing, China. PLoS ONE |
| title | A serological survey of antibodies to H5, H7 and H9 avian influenza viruses amongst the duck-related workers in Beijing, China. |
| title_full | A serological survey of antibodies to H5, H7 and H9 avian influenza viruses amongst the duck-related workers in Beijing, China. |
| title_fullStr | A serological survey of antibodies to H5, H7 and H9 avian influenza viruses amongst the duck-related workers in Beijing, China. |
| title_full_unstemmed | A serological survey of antibodies to H5, H7 and H9 avian influenza viruses amongst the duck-related workers in Beijing, China. |
| title_short | A serological survey of antibodies to H5, H7 and H9 avian influenza viruses amongst the duck-related workers in Beijing, China. |
| title_sort | serological survey of antibodies to h5 h7 and h9 avian influenza viruses amongst the duck related workers in beijing china |
| url | http://europepmc.org/articles/PMC3511333?pdf=render |
| work_keys_str_mv | AT pengyang aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT chunnama aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT weixianshi aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT shujuancui aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT guilanlu aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT xiaominpeng aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT daitaozhang aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT yimengliu aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT huijieliang aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT yizhang aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT lizhang aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT hollyseale aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT quanyiwang aserologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT pengyang serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT chunnama serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT weixianshi serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT shujuancui serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT guilanlu serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT xiaominpeng serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT daitaozhang serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT yimengliu serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT huijieliang serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT yizhang serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT lizhang serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT hollyseale serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina AT quanyiwang serologicalsurveyofantibodiestoh5h7andh9avianinfluenzavirusesamongsttheduckrelatedworkersinbeijingchina |