Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases
Abstract Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by all tested types of brain cells. Being a key intercellular communicator, EVs have emerged as a key contributor to the pathogenesis of various neurodegenerative diseases (NDs) including Alzheimer’s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
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| Series: | Translational Neurodegeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40035-022-00330-0 |
| _version_ | 1798005361142136832 |
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| author | Xiaohuan Xia Yi Wang Jialin C. Zheng |
| author_facet | Xiaohuan Xia Yi Wang Jialin C. Zheng |
| author_sort | Xiaohuan Xia |
| collection | DOAJ |
| description | Abstract Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by all tested types of brain cells. Being a key intercellular communicator, EVs have emerged as a key contributor to the pathogenesis of various neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease through delivery of bioactive cargos within the central nervous system (CNS). Importantly, CNS cell-derived EVs can be purified via immunoprecipitation, and EV cargos with altered levels have been identified as potential biomarkers for the diagnosis and prognosis of NDs. Given the essential impact of EVs on the pathogenesis of NDs, pathological EVs have been considered as therapeutic targets and EVs with therapeutic effects have been utilized as potential therapeutic agents or drug delivery platforms for the treatment of NDs. In this review, we focus on recent research progress on the pathological roles of EVs released from CNS cells in the pathogenesis of NDs, summarize findings that identify CNS-derived EV cargos as potential biomarkers to diagnose NDs, and comprehensively discuss promising potential of EVs as therapeutic targets, agents, and drug delivery systems in treating NDs, together with current concerns and challenges for basic research and clinical applications of EVs regarding NDs. |
| first_indexed | 2024-04-11T12:37:47Z |
| format | Article |
| id | doaj.art-8576f638bc284f4db80e8b0db5e26081 |
| institution | Directory Open Access Journal |
| issn | 2047-9158 |
| language | English |
| last_indexed | 2024-04-11T12:37:47Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Neurodegeneration |
| spelling | doaj.art-8576f638bc284f4db80e8b0db5e260812022-12-22T04:23:34ZengBMCTranslational Neurodegeneration2047-91582022-12-0111113110.1186/s40035-022-00330-0Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseasesXiaohuan Xia0Yi Wang1Jialin C. Zheng2Center for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital, Tongji University School of MedicineShanghai Frontiers Science Center of Nanocatalytic MedicineCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital, Tongji University School of MedicineAbstract Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by all tested types of brain cells. Being a key intercellular communicator, EVs have emerged as a key contributor to the pathogenesis of various neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease through delivery of bioactive cargos within the central nervous system (CNS). Importantly, CNS cell-derived EVs can be purified via immunoprecipitation, and EV cargos with altered levels have been identified as potential biomarkers for the diagnosis and prognosis of NDs. Given the essential impact of EVs on the pathogenesis of NDs, pathological EVs have been considered as therapeutic targets and EVs with therapeutic effects have been utilized as potential therapeutic agents or drug delivery platforms for the treatment of NDs. In this review, we focus on recent research progress on the pathological roles of EVs released from CNS cells in the pathogenesis of NDs, summarize findings that identify CNS-derived EV cargos as potential biomarkers to diagnose NDs, and comprehensively discuss promising potential of EVs as therapeutic targets, agents, and drug delivery systems in treating NDs, together with current concerns and challenges for basic research and clinical applications of EVs regarding NDs.https://doi.org/10.1186/s40035-022-00330-0Extracellular vesicleExosomeNeurodegenerative diseaseTherapeuticsBiomarker |
| spellingShingle | Xiaohuan Xia Yi Wang Jialin C. Zheng Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases Translational Neurodegeneration Extracellular vesicle Exosome Neurodegenerative disease Therapeutics Biomarker |
| title | Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases |
| title_full | Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases |
| title_fullStr | Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases |
| title_full_unstemmed | Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases |
| title_short | Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases |
| title_sort | extracellular vesicles from the pathogenesis to the therapy of neurodegenerative diseases |
| topic | Extracellular vesicle Exosome Neurodegenerative disease Therapeutics Biomarker |
| url | https://doi.org/10.1186/s40035-022-00330-0 |
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