Mesenchymal Stem Cells in Radiation-Induced Pulmonary Fibrosis: Future Prospects
Radiation-induced pulmonary fibrosis (RIPF) is a general and fatal side effect of radiotherapy, while the pathogenesis has not been entirely understood yet. By now, there is still no effective clinical intervention available for treatment of RIPF. Recent studies revealed mesenchymal stromal cells (M...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/1/6 |
| _version_ | 1797626120740274176 |
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| author | Yusha Chen Xuefeng Liu Zhaohui Tong |
| author_facet | Yusha Chen Xuefeng Liu Zhaohui Tong |
| author_sort | Yusha Chen |
| collection | DOAJ |
| description | Radiation-induced pulmonary fibrosis (RIPF) is a general and fatal side effect of radiotherapy, while the pathogenesis has not been entirely understood yet. By now, there is still no effective clinical intervention available for treatment of RIPF. Recent studies revealed mesenchymal stromal cells (MSCs) as a promising therapy treatment due to their homing and differentiation ability, paracrine effects, immunomodulatory effects, and MSCs-derived exosomes. Nevertheless, problems and challenges in applying MSCs still need to be taken seriously. Herein, we reviewed the mechanisms and challenges in the applications of MSCs in treating RIPF. |
| first_indexed | 2024-03-11T10:05:58Z |
| format | Article |
| id | doaj.art-85772bf2f2c1432fa761eff443827566 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T10:05:58Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-85772bf2f2c1432fa761eff4438275662023-11-16T15:04:48ZengMDPI AGCells2073-44092022-12-01121610.3390/cells12010006Mesenchymal Stem Cells in Radiation-Induced Pulmonary Fibrosis: Future ProspectsYusha Chen0Xuefeng Liu1Zhaohui Tong2Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, ChinaDepartments of Pathology, Urology, and Radiation Oncology, College of Medicine, OSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USADepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, ChinaRadiation-induced pulmonary fibrosis (RIPF) is a general and fatal side effect of radiotherapy, while the pathogenesis has not been entirely understood yet. By now, there is still no effective clinical intervention available for treatment of RIPF. Recent studies revealed mesenchymal stromal cells (MSCs) as a promising therapy treatment due to their homing and differentiation ability, paracrine effects, immunomodulatory effects, and MSCs-derived exosomes. Nevertheless, problems and challenges in applying MSCs still need to be taken seriously. Herein, we reviewed the mechanisms and challenges in the applications of MSCs in treating RIPF.https://www.mdpi.com/2073-4409/12/1/6mesenchymal stem cellsradiation-induced pulmonary fibrosisexosomestherapy |
| spellingShingle | Yusha Chen Xuefeng Liu Zhaohui Tong Mesenchymal Stem Cells in Radiation-Induced Pulmonary Fibrosis: Future Prospects Cells mesenchymal stem cells radiation-induced pulmonary fibrosis exosomes therapy |
| title | Mesenchymal Stem Cells in Radiation-Induced Pulmonary Fibrosis: Future Prospects |
| title_full | Mesenchymal Stem Cells in Radiation-Induced Pulmonary Fibrosis: Future Prospects |
| title_fullStr | Mesenchymal Stem Cells in Radiation-Induced Pulmonary Fibrosis: Future Prospects |
| title_full_unstemmed | Mesenchymal Stem Cells in Radiation-Induced Pulmonary Fibrosis: Future Prospects |
| title_short | Mesenchymal Stem Cells in Radiation-Induced Pulmonary Fibrosis: Future Prospects |
| title_sort | mesenchymal stem cells in radiation induced pulmonary fibrosis future prospects |
| topic | mesenchymal stem cells radiation-induced pulmonary fibrosis exosomes therapy |
| url | https://www.mdpi.com/2073-4409/12/1/6 |
| work_keys_str_mv | AT yushachen mesenchymalstemcellsinradiationinducedpulmonaryfibrosisfutureprospects AT xuefengliu mesenchymalstemcellsinradiationinducedpulmonaryfibrosisfutureprospects AT zhaohuitong mesenchymalstemcellsinradiationinducedpulmonaryfibrosisfutureprospects |