High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias

High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias

Evaluation of proarrhythmic properties is critical for drug discovery. In particular, QT prolongation in electrocardiograms has been utilized as a surrogate marker in many evaluation systems to assess the risk of torsade de pointes and lethal ventricular arrhythmia. Recently, new evaluation systems...

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Bibliographic Details
Main Authors: Yayoi Honda, Jun Li, Aya Hino, Shinji Tsujimoto, Jong-Kook Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
human iPS cell-derived atrial-like cardiomyocytes
nodal-like cardiomyoyctes
atrial arrhythmias
sick sinus syndrome
drug screening
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.680618/full

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