Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football
IntroductionWe examined postmortem brain tissue from men, over the age of 50, for chronic traumatic encephalopathy neuropathologic change (CTE-NC). We hypothesized that (i) a small percentage would have CTE-NC, (ii) those who played American football during their youth would be more likely to have C...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1143882/full |
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| author | Grant L. Iverson Grant L. Iverson Grant L. Iverson Grant L. Iverson Grant L. Iverson Pouya Jamshidi Amanda O. Fisher-Hubbard Amy Deep-Soboslay Thomas M. Hyde Thomas M. Hyde Thomas M. Hyde Joel E. Kleinman Joel E. Kleinman Joyce L. deJong Claire E. Shepherd Claire E. Shepherd Lili-Naz Hazrati Rudolph J. Castellani |
| author_facet | Grant L. Iverson Grant L. Iverson Grant L. Iverson Grant L. Iverson Grant L. Iverson Pouya Jamshidi Amanda O. Fisher-Hubbard Amy Deep-Soboslay Thomas M. Hyde Thomas M. Hyde Thomas M. Hyde Joel E. Kleinman Joel E. Kleinman Joyce L. deJong Claire E. Shepherd Claire E. Shepherd Lili-Naz Hazrati Rudolph J. Castellani |
| author_sort | Grant L. Iverson |
| collection | DOAJ |
| description | IntroductionWe examined postmortem brain tissue from men, over the age of 50, for chronic traumatic encephalopathy neuropathologic change (CTE-NC). We hypothesized that (i) a small percentage would have CTE-NC, (ii) those who played American football during their youth would be more likely to have CTE-NC than those who did not play contact or collision sports, and (iii) there would be no association between CTE-NC and suicide as a manner of death.MethodsBrain tissue from 186 men and accompanying clinical information were obtained from the Lieber Institute for Brain Development. Manner of death was determined by a board-certified forensic pathologist. Information was obtained from next of kin telephone interviews, including medical, social, demographic, family, and psychiatric history. The 2016 and 2021 consensus definitions were used for CTE-NC. Two authors screened all cases, using liberal criteria for identifying “possible” CTE-NC, and five authors examined the 15 selected cases.ResultsThe median age at the time of death was 65 years (interquartile range = 57–75; range = 50–96). There were 25.8% with a history of playing American football and 36.0% who had suicide as their manner of death. No case was rated as definitively having “features” of CTE-NC by all five authors. Ten cases were rated as having features of CTE-NC by three or more authors (5.4% of the sample), including 8.3% of those with a personal history of playing American football and 3.9% of those who did not play contact or collision sports. Of those with mood disorders during life, 5.5% had features of CTE-NC compared to 6.0% of those who did not have a reported mood disorder. Of those with suicide as a manner of death, 6.0% had features of CTE-NC compared to 5.0% of those who did not have suicide as a manner of death.DiscussionWe did not identify a single definitive case of CTE-NC, from the perspective of all raters, and only 5.4% of cases were identified as having possible features of CTE-NC by some raters. CTE-NC was very uncommon in men who played amateur American football, those with mood disorders during life, and those with suicide as a manner of death. |
| first_indexed | 2024-03-13T04:40:26Z |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T04:40:26Z |
| publishDate | 2023-06-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-857b1001775f471c9183059d1508598a2023-06-19T05:55:07ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-06-011410.3389/fneur.2023.11438821143882Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American footballGrant L. Iverson0Grant L. Iverson1Grant L. Iverson2Grant L. Iverson3Grant L. Iverson4Pouya Jamshidi5Amanda O. Fisher-Hubbard6Amy Deep-Soboslay7Thomas M. Hyde8Thomas M. Hyde9Thomas M. Hyde10Joel E. Kleinman11Joel E. Kleinman12Joyce L. deJong13Claire E. Shepherd14Claire E. Shepherd15Lili-Naz Hazrati16Rudolph J. Castellani17Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, United StatesDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, MA, United StatesDepartment of Physical Medicine and Rehabilitation, Schoen Adams Research Institute at Spaulding Rehabilitation, Charlestown, MA, United StatesMassGeneral Hospital for Children Sports Concussion Program, Boston, MA, United StatesHome Base, A Red Sox Foundation and Massachusetts General Hospital Program, Charlestown, MA, United StatesDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Pathology, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, United StatesLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, United StatesLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, United StatesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States0Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United StatesLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, United StatesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Pathology, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, United States1Neuroscience Research Australia, Randwick, NSW, Australia2School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, CanadaDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesIntroductionWe examined postmortem brain tissue from men, over the age of 50, for chronic traumatic encephalopathy neuropathologic change (CTE-NC). We hypothesized that (i) a small percentage would have CTE-NC, (ii) those who played American football during their youth would be more likely to have CTE-NC than those who did not play contact or collision sports, and (iii) there would be no association between CTE-NC and suicide as a manner of death.MethodsBrain tissue from 186 men and accompanying clinical information were obtained from the Lieber Institute for Brain Development. Manner of death was determined by a board-certified forensic pathologist. Information was obtained from next of kin telephone interviews, including medical, social, demographic, family, and psychiatric history. The 2016 and 2021 consensus definitions were used for CTE-NC. Two authors screened all cases, using liberal criteria for identifying “possible” CTE-NC, and five authors examined the 15 selected cases.ResultsThe median age at the time of death was 65 years (interquartile range = 57–75; range = 50–96). There were 25.8% with a history of playing American football and 36.0% who had suicide as their manner of death. No case was rated as definitively having “features” of CTE-NC by all five authors. Ten cases were rated as having features of CTE-NC by three or more authors (5.4% of the sample), including 8.3% of those with a personal history of playing American football and 3.9% of those who did not play contact or collision sports. Of those with mood disorders during life, 5.5% had features of CTE-NC compared to 6.0% of those who did not have a reported mood disorder. Of those with suicide as a manner of death, 6.0% had features of CTE-NC compared to 5.0% of those who did not have suicide as a manner of death.DiscussionWe did not identify a single definitive case of CTE-NC, from the perspective of all raters, and only 5.4% of cases were identified as having possible features of CTE-NC by some raters. CTE-NC was very uncommon in men who played amateur American football, those with mood disorders during life, and those with suicide as a manner of death.https://www.frontiersin.org/articles/10.3389/fneur.2023.1143882/fullneuropathologytausuicideautopsydepression |
| spellingShingle | Grant L. Iverson Grant L. Iverson Grant L. Iverson Grant L. Iverson Grant L. Iverson Pouya Jamshidi Amanda O. Fisher-Hubbard Amy Deep-Soboslay Thomas M. Hyde Thomas M. Hyde Thomas M. Hyde Joel E. Kleinman Joel E. Kleinman Joyce L. deJong Claire E. Shepherd Claire E. Shepherd Lili-Naz Hazrati Rudolph J. Castellani Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football Frontiers in Neurology neuropathology tau suicide autopsy depression |
| title | Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football |
| title_full | Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football |
| title_fullStr | Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football |
| title_full_unstemmed | Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football |
| title_short | Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football |
| title_sort | chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur american football |
| topic | neuropathology tau suicide autopsy depression |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1143882/full |
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